24-Hour Crisis Hotline: (877)SAFEGBC or (877)723-3422 Mental Health & Substance Abuse Issues

6502 Nursery Drive, Suite 100
Victoria, TX 77904
(361)575-0611
(800)421-8825

Sleep Disorders
Resources
Basic InformationLatest News
Sleepless Nights, Unhealthy Hearts?Curbing Sleep Apnea Might Mean Fewer Night Trips to BathroomHealth Tip: Slipping Back Into SleepPast Prescribing Behavior Predicts Choice of Insomnia RxWhat Guides Docs' Sleeping Pill Picks? 'Same Old Same Old,' Study SaysSkimp on Sleep and You Just May Wind Up SickSleepless Nights Linked to Asthma Later in LifeThe ABCs of Good ZzzzzsLevel 3 Polysomnography Data Noninferior for OSAJury Still Out on Whether to Screen All Adults for Sleep ApneaHealth Tip: 5 Things to Help You Sleep SoundlyMany Misuse OTC Sleep Aids: SurveyHomeless, And Often Sleepless TooHealth Tip: Struggling in the Morning?VA ECHO Program Feasible for Management of Sleep DisordersStudy Finds Genetic Link Between Sleep Problems and ObesityStudy Sees Link Between Insomnia, AsthmaWeb-Based Help for Insomnia Shows PromiseHealth Tip: When Sleep is InterruptedCPAP Improves Asthma Control, QoL for Adults With Asthma, OSASleep Apnea May Boost Risk for Post-Op ProblemsHome-Based CBT Program for Sleep Feasible in PregnancyHealth Tip: Making the Transition to SleepSleep Troubles, Heart Troubles?Why Some Women Find Good Sleep Tough to GetSleep Apnea Diagnoses Up Among Outpatients From 1993 to 2010For Those With Sleep Apnea, Maybe It's Time for a Driving TestMouse Study Suggests Brain Circuit Involved in Sleep-Wake CycleRisk of Cardiovascular Events Not Reduced With CPAP UseNighttime Sleep Disturbance Common in Chronic PainResistant Hypertension Linked to Increased Risk of Sleep ApneaDrowsy Driving Causes 1 in 5 Fatal Crashes: ReportStudy Links Sleep Problems to Stroke Risk, RecoveryHealth Tip: Considering a Sleep Study?Sleep Disorders 6 Times Higher Among VeteransHealth Tip: Exercise for Better SleepSleep Apnea Tied to Complications After AngioplastyUSPSTF Finds Evidence Lacking for Sleep Apnea ScreeningShift Work 'Unwinds' Body Clock, May Lead to More Severe StrokeShift Workers at Greater Risk of Heart Ills, Study SaysYoung Children With Sleep Apnea May Face Learning Difficulties: StudySevere, Untreated Sleep Apnea Linked to Aggressive MelanomaSleep Apnea May Raise Heart Risks in People With PacemakersDesperate for Shut-Eye?New Six-Item Scale Predicts Sleep Apnea in ChildrenSleep Doesn't Come Easy to Those With Brain InjuriesAssociated Professional Sleep Societies, June 5-9, 2010
Questions and AnswersLinks
Related Topics

Medical Disorders
Mental Disorders

Shift Work 'Unwinds' Body Clock, May Lead to More Severe Stroke


HealthDay News
Updated: Jun 8th 2016

new article illustration

WEDNESDAY, June 8, 2016 (HealthDay News) -- Circadian rhythm disruption associated with shifted light:dark (LD) cycles exacerbates stroke outcomes in a rat model, according to an experimental study published online June 2 in Endocrinology.

David J. Earnest, Ph.D., from the Texas A&M Health Science Center in Bryan, and colleagues observed male and female rats during exposure to a fixed LD 12:12 cycle and a shifted (12 hour advance/five days) cycle for about seven weeks.

The researchers found that circadian entrainment of activity rhythms was severely disrupted when the LD cycle was routinely shifted. In all shifted LD females, cyclicity was abolished and persistent estrus was evident. The estrous cyclicity disruption correlated with a significant increase in serum estradiol levels relative to those seen in fixed LD controls. In shifted LD male and female rats, circadian rhythm disruption exacerbated stroke outcomes and further amplified sex differences in stroke impairments. After exposure to the shifted LD cycle, circadian disruption correlated with a high rate of mortality in males, but not females. Following exposure to shifted LD cycles, circadian desynchronization correlated with significant increases in stroke-induced infarct volume and sensorimotor deficits, with corresponding decreases in serum insulin-like growth factor-1 levels in surviving females.

"These results suggest that circadian rhythm disruption associated with shift work schedules or the irregular nature of our everyday work and/or social environments may interact with other non-modifiable risk factors such as biological sex to modulate the pathological effects of stroke," the authors write.

Abstract
Full Text