24-Hour Crisis Hotline: (877)SAFEGBC or (877)723-3422 Mental Health & Substance Abuse Issues

6502 Nursery Drive, Suite 100
Victoria, TX 77904
(361)575-0611
(800)421-8825

Child & Adolescent Development: Overview
Resources
Basic InformationMore InformationLatest News
Many Kids With Diabetes Missing Out on Eye Exams, Study FindsOlder Mothers May Raise Better-Behaved Kids, Study SuggestsHealth Tip: Check Your Child's TemperatureFruit Juice for Kids: A Serving a Day OK'Eraser Challenge' Latest Harmful Social Media Trend for Kids'Heads Up' Football Program Tackles Concussion Danger in KidsParents Don't Always Head to Child's Doctor When Illness StrikesSpring-Clean Your Medicine Cabinet to Safeguard Your KidsFewer U.S. Kids Overdosing on OpioidsWhy Some Kids Take Longer to Recover From Brain InjuryNearby Day Cares Don't Pose Health Risks to Kids: StudyObese Moms May Fail to Spot Obesity in Their Own KidsToo Much Screen Time May Raise Kids' Diabetes RiskHealth Tip: Help Kids Maintain Healthy CholesterolMite-Proof Bedding May Help Curb Asthma Attacks: StudyWatchful Waiting Cost-Effective for Pediatric Acute Otitis MediaHealth Tip: Make Sure Kids' Shoes Fit WellCity Tax on Cars Cut Pollution, Kids' Asthma RiskKidney Transplant Survival Up Among Babies, KidsSecondhand Smoke Linked to Food Allergies in KidsObesity May Raise Girls' Risk of Asthma, AllergiesDisabled Kids at Higher Risk of Abuse, Study FindsNasal 'Nerve Block' May Help Ease Kids' MigrainesCan Mom's Vitamin E Head Off Child's Asthma Risk?Asthma Much More Lethal for Black Children, Study FindsInsecticides Linked to Behavioral Issues in ChildrenCould Common Insecticides Be Tied to Behavior Issues in Kids?Complication Rates Often Higher in Youth With T2DM Versus T1DMChildhood Cancer Survivors Living LongerYouth With Type 2 Diabetes Often Face ComplicationsKids Mean Less Shuteye for Mom, While Dad Slumbers On'Superbug' Infections Striking More U.S. KidsHeadaches Often Strike Before Strokes in Kids: StudyACL Tears on the Rise Among Kids, Especially GirlsLearning Issues Common in Kids With Heart Defects: StudyAAP Policy Statement Focuses on Child Witness Well-BeingKids Born to Older Moms Score Higher on Thinking TestsThere's Fun and Fitness in the Pool for Asthmatic KidsMost Parents Don't Think They're Meeting Kids' Nutritional NeedsKids' OD Risk Rises When Opioids Left Out at HomeAntibiotics Could Be Alternative to Surgery for AppendicitisIs Surgery Always Needed for Kids' Appendicitis?Health Tip: Give Your Kids Bone-Building FoodLow-Income Kids More Likely to Have ADHD, AsthmaTougher Alcohol Laws Mean Fewer Young People Killed on the RoadHealth Tip: Protect Kids in Cold WeatherNeeded: An 'Action Plan' for Kids Prone to Severe Allergic ReactionsBe Your Child's ValentineAmbient Air Pollution May Raise T2DM Risk in Hispanic ChildrenWinning the Veggie Wars With Kids
Questions and AnswersLinks
Related Topics

ADHD: Attention Deficit Hyperactivity Disorder
Childhood Mental Disorders and Illnesses
Child Development & Parenting: Infants (0-2)
Child Development & Parenting: Early (3-7)

Prenatal BPA Exposure May Dampen Body's Fullness Cues


HealthDay News
Updated: Feb 8th 2017

new article illustration

WEDNESDAY, Feb. 8, 2017 (HealthDay News) -- Prenatal exposure to bisphenol A (BPA) may raise a child's risk of obesity by altering hypothalamic circuits that regulate feeding behavior and energy balance, according to an experimental study published online Feb. 7 in Endocrinology.

Harry MacKay, Ph.D., from the Baylor College of Medicine in Houston, and colleagues examined leptin sensitivity and hypothalamic structure in young BPA-exposed animals before onset of a body weight or metabolic phenotype. They exposed pregnant and lactating CD-1 mice to BPA or diethylstilbestrol (DES) at low, environmentally relevant doses.

The researchers found that young adult offspring were resistant to leptin-induced suppression of food intake, body weight loss, and hypothalamic pro-opiomelanocortin (POMC) upregulation. Reduced density of POMC projections into the paraventricular hypothalamus (PVN) was seen for male and female BPA-exposed mice. BPA- and DES-exposed pups had delayed and blunted postnatal leptin surges, respectively; in female BPA-exposed animals given daily injections of supplemental leptin, POMC projections into the PVN were rescued.

"Our findings suggest that BPA, a putative obesogen, may exert its effects through developmental programming of the hypothalamic melanocortin circuitry, permanently altering the neurobiology of metabolic homeostasis," the authors write.

Full Text (subscription or payment may be required)