24-Hour Crisis Hotline: (877)SAFEGBC or (877)723-3422 Mental Health & Substance Abuse Issues

6502 Nursery Drive, Suite 100
Victoria, TX 77904
(361)575-0611
(800)421-8825

Medical Disorders
Resources
Basic InformationLookupsLatest News
Is Obesity Slowing Gains in U.S. Life Spans?Hold That Sneeze? Maybe NotSauna Sessions May Be as Good as Exercise for the HeartFor Kids, Chronic Illness May Trigger Mental Health IssuesWildfires Can Affect Air Quality Far From the FlamesConsiderable Economic Burden for Asthma in United StatesDuration of Diabetes, Prediabetes Linked to Presence of CACYour Dishwasher Is Not as Sterile as You ThinkHealth Tip: Recognize Symptoms of Food PoisoningOld Age Alone Not to Blame for Surgical ComplicationsAsthma in America Carries $82 Billion Price TagPsoriasis Is Independent Risk Factor for Comorbidity in ChildrenCore Muscle Weakness Increases Spinal Loading, Back InjuriesFDA Bans Use of Opioid-Containing Cough Meds by KidsCan Deportation Fears Hurt the Heart?Health Tip: Maintain Brain Health'Bone Cement': A Non-Surgical Option for Painful Joints?Some Patients Would Choose Antibiotics for AppendicitisStudy Gets to the Core of Back Pain in RunnersComplete Handover of Anesthesia Care May Up ComplicationsSchool-Based Telemedicine Asthma Management Is EffectiveProvider Counseling of Exercise for Arthritis Patients ImprovedSurgery or Antibiotics for Appendicitis? Here's What Patients ChoseIs Surgery Riskier for Black Children?Vitamin D Supplements May Make Arteries HealthierMental Disorders Common in Kids With Chronic Physical ConditionsWhat to Do if Your Child Has ChickenpoxPain Self-Efficacy Questionnaire Helps to Evaluate Migraine PainAdjuvanted Shingles Subunit Vaccine Likely More Cost-EffectiveSpike Seen in Kids' Eye Injuries From BB, Paintball GunsFor Poorer Americans, Stress Brings Worse HealthRespiratory Virus Lurks as Wintertime WorryHow to Get Your Health on Track for 2018Beware Carbon Monoxide Dangers When Cold Weather StrikesStatic Perimetry Approach May Be Better for Kids With GlaucomaMom-to-Be's Immune Response May Trigger Zika Birth DefectsHealth Tip: Avoid Kidney DiseaseClean Air Act May Be Saving More Lives Than ThoughtRacial/Ethnic Disparities Up for Live Donor Kidney TransplantScripted Callbacks Do Not Prevent 30-Day Returns of ER DischargesHealth Tip: Stay WellSerum Caffeine, Metabolites May Predict Early Parkinson's DiseaseHysterectomy May Have Long-Term Health RisksStem Cell Transplant Shows Promise for Immune Disorder SclerodermaCan Caffeine Levels in Blood Predict Parkinson's?New Hope for 'Ringing' in the EarsBroader Statin Use Improves Atherosclerotic CVD Prevention10 Percent of Heart Recipients Develop De Novo MalignancyProtect Your Heart in Frigid WeatherAtopic Dermatitis Associated With Higher Risk of Skin Cancer
Questions and AnswersLinks
Related Topics

Diabetes

Vitamin D Supplements Improve Markers of Bone Turnover in CKD


HealthDay News
Updated: Oct 25th 2017

new article illustration

WEDNESDAY, Oct. 25, 2017 (HealthDay News) -- For patients with chronic kidney disease (CKD), cholecalciferol supplementation can correct vitamin D deficiency and improve markers of bone turnover, according to a study published online Oct. 17 in the Journal of Bone and Mineral Research.

Ashok Kumar Yadav, Ph.D., from the Postgraduate Institute of Medical Education and Research in India, and colleagues examined bone turnover among subjects who completed a randomized trial examining the effect of cholecalciferol supplementation on vascular function in patients without diabetes who had CKD stage G3-4 and vitamin D ≤20ng/ml. Participants were randomized to receive two oral doses of 300,000 IU cholecalciferol or matching placebo at baseline and eight weeks (58 and 59 patients, respectively, completed the study).

The researchers found that there was a significant increase in serum 25-hydroxyvitamin D (25[OH]D) and 1,25-dihydroxycholecalciferol (1,25[OH]2D) levels in the cholecalciferol group at 16 weeks but not in the placebo group. There was a significant decrease in intact parathyroid hormone (iPTH) in the cholecalciferol group. Significant reductions were seen in serum total and bone-specific alkaline phosphatase (SAP, BAP) and serum C-terminal cross-linked collagen type I telopeptides (CTX-1) in the cholecalciferol group. Significant correlations were seen for Δ25(OH)D with ΔiPTH, Δ1,25(OH)2D, ΔSAP, ΔBAP, and ΔCTX-1 in correlation analysis.

"Cholecalciferol supplementation corrects vitamin D deficiency and is effective in lowering serum intact parathyroid hormone and bone turnover markers in early stages of CKD," the authors write.

Abstract
Full Text (subscription or payment may be required)