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Certain Antibiotics Tied to Deadly Heart Vessel Tears: FDA

HealthDay News
by By E.J. Mundell
HealthDay Reporter
Updated: Dec 21st 2018

new article illustration

FRIDAY, Dec. 21, 2018 (HealthDay News) -- Patients should avoid a class of antibiotics called fluoroquinolones due to an increased risk of heart vessel tears associated with their use, the U.S. Food and Drug Administration warned.

"These tears, called aortic dissections, or ruptures of an aortic aneurysm can lead to dangerous bleeding or even death," the agency said in a statement issued Thursday.

The risk for these ruptures rises with the use of fluoroquinolone antibiotics delivered by injection or as a pill, and the drugs "should not be used in patients at increased risk unless there are no other treatment options available," the FDA added.

Fluoroquinolones have been a mainstay of antibiotic therapy, particularly for upper respiratory conditions, and have been around for more than three decades. They include Cipro (ciprofloxacin), Levaquin (levofloxacin), Factive, (gemifloxacin), and Avelox ( moxifloxacin).

Certain groups are especially vulnerable, the FDA said.

"People at increased risk include those with a history of blockages or aneurysms (abnormal bulges) of the aorta or other blood vessels, high blood pressure, certain genetic disorders that involve blood vessel changes, and the elderly," according to the FDA.

Before taking an antibiotic, patients should always inform their physician of any history of aneurysm, hardening of the arteries, high blood pressure or genetic conditions, such as Marfan syndrome and Ehlers-Danlos syndrome.

One cardiologist said the new announcement can help physicians.

"Antibiotics, when used appropriately, save lives," said Dr. Satjit Bhusri, a cardiologist at Lenox Hill Hospital in New York City. "With this new warning from the FDA regarding increased risk of aortic rupture, caution should be given to those at risk. Screening by a cardiologist prior to starting these antibiotics is the best prevention. An ultrasound of the heart and aorta is a simple, non-invasive and life-saving tool."

For those people who already taking a fluoroquinolone antibiotic, "do not stop the antibiotic without first talking to your healthcare professional," the FDA advised.

Of course, people should seek medical help at any sign of aortic aneurysm.

"Patients should seek medical attention immediately by going to an emergency room or calling 911 if you experience sudden, severe, and constant pain in the stomach, chest or back," the FDA said. "Be aware that symptoms of an aortic aneurysm often do not show up until the aneurysm becomes large or bursts, so report any unusual side effects from taking fluoroquinolones to your healthcare professional immediately."

There's one other group that may want to avoid fluoroquinolone antibiotics, although for another reason.

"Physicians should avoid using them in younger patients and teenagers that are very active, especially playing sports," said Dr. Theodore Strange, associate chair of medicine at Staten Island University Hospital in New York City. He said prior research has shown that the use of fluoroquinolones has been linked to a heightened risk of tendon injury.

More information

Find out more about aortic aneurysm at the American Heart Association.