24-Hour Crisis Hotline: (877)SAFEGBC or (877)723-3422 Mental Health & Substance Abuse Issues

6502 Nursery Drive, Suite 100
Victoria, TX 77904
(361)575-0611
(800)421-8825
Fax: (361)578-5500

Medical Disorders
Resources
Basic InformationLookupsLatest News
Vaping Constricts Blood Vessels, Raising Heart, Lung ConcernsWhen Does Heart Health Return to Normal After Quitting Smoking?New Antibiotic Approved for Community-Acquired Bacterial PneumoniaImplant Approved to Improve Symptoms in Advanced Heart Failure'No Quick Fix' for A-Fib, But Cardiologist Says You Can Help Prevent ItAHA News: Why Do Women Get Statins Less Frequently Than Men?'Dr. Google' Helps Some Patients Diagnose a Rare DiseaseHealth Tip: Recognizing a Staph InfectionIs Dairy Fat Different?CDC Recommends Catch-Up HPV Vaccination for Young AdultsHow to Relieve Dry, Irritated EyesPretomanid Approved for Treatment of Drug-Resistant TBAHA News: Tiring Easily May Warn of Future Heart TroubleAmerica's Obesity Epidemic May Mean Some Cancers Are Striking SoonerHeavy Smog as Bad as Pack-a-Day Smoking for LungsConcussed NFL Players Sidelined for Much Longer NowadaysHormone Therapy for Prostate Cancer Might Harm the Heart: StudyObesity and 'Spare Tire' Raise Hispanics' Odds for Early DeathAHA News: Protein Made During Long Workouts May Warn of Heart ProblemsHow to Help Your Heart Weather Extreme HeatHealth Threats Don't End for Some Sepsis SurvivorsHeat Waves Brought by Climate Change Could Prove Deadly for Kidney PatientsHealth Tip: Avoiding AnemiaAre You Still Putting Off Colon Cancer Screening?Tips for Preventing DiverticulitisFDA Reports More Seizures Among VapersKids Getting Too Many Opioids After TonsillectomyCan Major Surgeries Cause a Long-Term 'Brain Drain'?How Much Coffee Is Too Much for Migraine Sufferers?Steady Stream of Lesser Head Hits in Football Can Still Damage BrainDon't Sweat It: Hyperhydrosis Can Be TreatedFast-Food Joints on Your Way to Work? Your Waistline May WidenAdults Need Vaccines, TooHealth Tip: Managing Arthritis of the Hands'Selfies' Might Someday Track Your Blood PressureIn Heat Waves, Fans May Do More Harm Than GoodSmoking Creates Long-Lasting Risk for Clogged Leg ArteriesFootball Head Trauma Linked Again to Long-Term Brain DamageDrug Approved to Treat Tenosynovial Giant Cell TumorRugby-Style Tackling Might Make Football SaferFor Kids With Asthma, Allergies, New School Year Can Bring Flare-UpsFrailty Not a Normal Part of AgingAHA News: Hurricane Checklist: Batteries, Bottled Water – And A Plan for Heart CareDangerous Sesame Allergy Affects Many AmericansScorching Pavement Sends Some to the ER With BurnsHealth Tip: Living With Hypoglycemia3-D Printers Might Someday Make Replacement HeartsCDC Renews Pledge to Fight Ebola Outbreak in AfricaAnemia Linked to Higher Odds for Dementia in SeniorsDrug Duo May Be an Advance Against a Common Leukemia
Questions and AnswersLinks
Related Topics

Diabetes

New Antibiotic Treats Pneumonia, Skin Infections

HealthDay News
by By Amy NortonHealthDay Reporter
Updated: Feb 6th 2019

new article illustration

WEDNESDAY, Feb. 6, 2019 (HealthDay News) -- An updated version of an old antibiotic works well against pneumonia and serious skin infections -- giving doctors a new option for some common ills, researchers say.

In two trials, researchers found that the drug -- called omadacycline -- worked as well as standard antibiotics in treating patients with "community-acquired" pneumonia or skin infections.

That means they got sick out in the real world, rather than developing the infections while in the hospital -- which are typically more severe.

The U.S. Food and Drug Administration approved omadacycline in October, when the agency reviewed the trial findings. The results are now being published in the Feb. 7 issue of the New England Journal of Medicine.

The drug is a revamped, "modernized" tetracycline, explained senior researcher Dr. Evan Loh, president of Paratek Pharmaceuticals, the Boston-based maker of omadacycline.

Tetracyclines have been around for decades, and during that time bacteria have developed ways to resist the drugs. It's one example of the wider problem of antibiotic resistance -- where long-used drugs are starting to lose their effectiveness against various bacterial infections.

Omadacycline was designed to thwart the two major mechanisms that bacteria use to evade tetracyclines, Loh explained.

In both of the new trials, his team found that omadacycline was as effective as the standard antibiotics linezolid and moxifloxacin.

In a nutshell, that means the drug "worked pretty well," said Dr. Henry Chambers, an infectious disease specialist at the University of California, San Francisco.

But Chambers, who wrote an editorial published with the studies, questioned how valuable that will ultimately be.

That's because doctors already have "pretty good options" for the infections treated in these trials, he said.

The biggest scourge, Chambers said, are those cases of pneumonia and other serious infections that are resistant to multiple existing antibiotics.

"That's where the real medical need is," he said.

Each year in the United States, at least 2 million people develop antibiotic-resistant infections, and upwards of 23,000 die, according to the U.S. Centers for Disease Control and Prevention.

One way to combat the problem is by developing new antibiotics that work through novel mechanisms, Chambers said. Alternatively, researchers can tweak existing drugs to overcome the methods bacteria used to render themselves treatment-resistant.

Omadacycline falls into that latter category.

One of the new trials focused on patients who had to be hospitalized after developing bacterial pneumonia. Loh's team randomly assigned 386 to treatment with omadacycline; another 388 were assigned to moxifloxacin. Both antibiotics were first given by IV once a day. After three days, patients could switch to pills.

Overall, 81 percent of omadacycline patients had an "early clinical response." That meant at least two of their symptoms -- such as chest pain, coughing and breathing problems -- improved significantly within three to five days.

That rate was just under 83 percent of patients on the standard antibiotic.

As for side effects, gastrointestinal woes -- nausea, vomiting and diarrhea -- were the most common issue with either antibiotic.

The effectiveness was similar in the second trial, of more than 600 patients with severe skin infections. Half were assigned to omadacycline, half to linezolid -- and the rates of early clinical response were about 85 percent in both groups.

Speaking to Chambers' point, Loh said that the new antibiotic is aimed at the type of patient who becomes sick out in the real world -- not the seriously ill hospital patient whose infection may resist the gamut of antibiotics.

"We're not the drug for that," Loh said.

On the other hand, he pointed out, there are reasons why certain patients cannot take the existing antibiotics: Some have conditions that put them at risk of rare, serious side effects, for example, while others are on medications that interact with the current drugs.

Omadacycline is another option, according to Loh.

He and Chambers also made this bigger point: No matter how many new antibiotics are created, the importance of "judicious" antibiotic use will never dim.

It's estimated that around half of antibiotic prescriptions in the United States are inappropriate, Chambers said.

"Inappropriate use has certainly been a big contributor to the problem we face now," he said.

More information

The U.S. Centers for Disease Control and Prevention has more on antibiotic resistance.