24-Hour Crisis Hotline: (877)SAFEGBC or (877)723-3422 Mental Health & Substance Abuse Issues

6502 Nursery Drive, Suite 100
Victoria, TX 77904
(361)575-0611
(800)421-8825

Medical Disorders
Resources
Basic InformationLookupsLatest News
AHA News: Emphysema May Raise Risk of Ruptured AneurysmsNew Facial Bone Might Someday Be Grown From the Patient's RibWhat Works Best for Women Struggling With a Leaky Bladder?Your Apple Watch Might Help Spot a Dangerous Irregular HeartbeatDocs Back Away From Low-Dose Aspirin for Heart Attack PreventionAHA News: Overweight Kids at Higher Risk for Blood Clots as AdultsEbola Survivors Continue to Suffer Years After RecoveryFewer Boys Are Suffering Head Injuries, But Rate Rises for GirlsAHA News: Black Woman in Their 50s Face Especially High Stroke RiskNew Drug Could Help Those With Tough-to-Treat CholesterolWhen Can Kids Return to Play After a Concussion?Need to Be Vaccinated? Try Your Local PharmacyOne-Third of U.S. Kids Have Back Pain, Study SaysBlacks, Hispanics Bear Burden of Air Pollution: StudyChickens Help Scientists Pinpoint Origin of Rare, Deadly VirusDry Eye and Migraines Might Be Linked: StudySkin Fungi May Be Tied to Bowel DiseaseYo-Yo Dieting Can Take a Toll on Your HeartAHA News: Opioid Meds Pose Danger to Kidney Disease PatientsHealth Tip: UTI Warning SignsStaph Infections Drop, but Levels Still Worry U.S. Health OfficialsTreatment May Allow Allergic Kids to Eat Eggs Safely: StudyAcne Drug Accutane May Not Depress Mood After AllHealth Tip: Preventing Carpal TunnelMajor Flooding Can Bring Skin Infection DangersSmall Trial Provides New Hope Against Parkinson's DiseaseIs Your Hand Pain Arthritis, Carpal Tunnel or Something Else?California Parents Are Getting Around Vaccine Law, Fueling Measles OutbreaksSeniors With UTIs Need Antibiotics ASAP, Study SaysWhy Do Some Kids With Eczema Develop Food Allergies?High-Fiber Diet May Help Gut 'Microbiome' Battle MelanomaTick Bites More Likely to Cause Red Meat Allergy Than ThoughtWalking, Not Riding, Boosts Health in Golfers With Knee WoesIs At-Home Stool Test a Viable Alternative to Colonoscopy?After Peanut Allergy Rx, Eating Small Bits of Peanut Might Help: StudyA Hard Look at Smoking's Effect on VisionPeanut Allergy Patch Shows Middling Results in TrialToxins in Home Furnishings Can Be Passed on to KidsKratom-Related Poisonings Are Soaring, Study FindsFDA Aims to Strengthen Sunscreen RulesBrain Condition CTE Seen in H.S. Football Players: StudyPregnant Women Should Delay Gallbladder Surgery, Study FindsGut Microbes May Help Drive Lupus, Study FindsMost Hip, Knee Replacements Last Decades, Study FindsAHA News: Living Near Convenience Stores Could Raise Risk of Artery-Clogging ConditionPossible Parkinson's 'Pandemic' Looms: Report'Apple-Shaped' Body? 'Pear-Shaped'? Your Genes May TellProtect Your Aging Eyes From Macular DegenerationKidney Failure Patients Face Higher Risk of Cancer DeathHow Inactivity and Junk Food Can Harm Your Brain
Questions and AnswersLinks
Related Topics

Diabetes

'Apple-Shaped' Body? 'Pear-Shaped'? Your Genes May Tell

HealthDay News
by By Amy Norton
HealthDay Reporter
Updated: Feb 18th 2019

new article illustration

MONDAY, Feb. 18, 2019 (HealthDay News) -- A large, new study has uncovered 24 genetic variations that help separate the apple-shaped people from the pear-shaped ones.

Researchers said the findings help explain why some people are prone to carrying any excess weight around the belly. But more importantly, they could eventually shed light on the biology of diseases linked to obesity -- particularly abdominal obesity.

While obesity is linked to a range of health conditions, excess fat around the middle seems to be a particular risk factor for certain diseases -- like type 2 diabetes and heart disease.

"But we haven't really known why," said lead researcher Ruth Loos, a professor at Mount Sinai's Icahn School of Medicine, in New York City.

So, her team dug into the genetics underlying body fat distribution. If researchers can learn about the important gene variants, Loos explained, they can better understand why some people develop diabetes or heart disease when they gain weight, while others do not.

The findings, published online Feb. 18 in Nature Genetics, come from a huge international research effort, looking at over 476,000 people at 70 research centers around the world.

Loos and her colleagues focused on hunting down so-called coding variations -- differences within genes that have the potential to alter the way that genes and their proteins function.

In the end, the scientists discovered two dozen coding variations that were associated with body fat distribution. Some of those variations have already been linked to processes such as blood sugar control and fat metabolism.

In general, Loos said, genes linked to obesity can be separated into two broad groups. One group acts on the brain, influencing how much you eat by regulating hunger and satiety.

"The gene variations we identified in this study don't act in the brain," Loos said. "They work at the cellular level, determining where fat will be stored in the body."

It all raises the possibility of developing medications that can "tweak" those genetic pathways so that body fat is redistributed in a healthier way, according to Loos.

But that's a long way off, she stressed.

The next step, Loos said, is to learn more about how these gene variations function in the body.

No one, however, is saying that body weight and shape are genetically set in stone.

Dr. Carl Lavie is medical director of cardiac rehabilitation and preventive cardiology at the Ochsner Heart and Vascular Institute, in New Orleans.

"Genes are involved in the development of obesity and where the fat is distributed," said Lavie. "However, the evidence is much stronger for environmental causes."

Those causes are no surprise: Lavie pointed to sedentary lifestyles and sugary, high-calorie diets.

"Regardless of a person's genetic profile," he said, "physical activity and reducing calorie intake can prevent obesity and abdominal obesity -- and prevent it from progressing."

Plus, Lavie noted, exercise boosts a person's cardiovascular fitness level -- which is a critical factor in the risk of developing or dying from heart disease.

Loos agreed that genes are not destiny. "Obesity is partly genetic," she said. "We should not forget that diet and exercise are very important."

However, she added, people with a genetic predisposition toward storing belly fat will have a harder time keeping a trim, heart-healthy waistline.

More information

The Harvard School of Public Health has more on obesity and genes.