24-Hour Crisis Hotline: (877)SAFEGBC or (877)723-3422 Mental Health & Substance Abuse Issues

6502 Nursery Drive, Suite 100
Victoria, TX 77904
(361)575-0611
(800)421-8825
Fax: (361)578-5500

Medical Disorders
Resources
Basic InformationLookupsLatest News
Global Coronavirus Outbreaks Raise Fears of PandemicGlobal Coronavirus Outbreaks Worry Experts, as U.S. Cases Reach 34Sticking With Meds Lowers Lupus Patients' Diabetes RiskU.S. Coronavirus Cases Reach 34: CDCAHA News: Research Opens New Avenues to Reduce Foot, Toe AmputationsYour Best Bet Against Heart Attack, Stroke? Lower Blood PressureLung Diseases on the Rise WorldwideNew China Coronavirus Cases Decline, 2 Passengers From Affected Cruise Ship DieAHA News: What Women Need to Know About Breast Cancer and Heart DiseaseU.S. Scientists Take Key Step Towards Towards Coronavirus VaccineQuarantine Ends on Cruise Ship in Japan as Coronavirus Cases Near 75,000AHA News: Race and Gender May Tip the Scales on Traditional Stroke Risk FactorsMeasles Complications Can Affect Every Organ: StudyBabies' Exposure to Household Cleaning Products Tied to Later Asthma RiskCoronavirus: Are U.S. Hospitals Prepared?14 Americans From Cruise Ship Hit By Coronavirus Test Positive for InfectionHot Chocolate Could Help Ease Painful Clogged Leg VesselsAntiviral Drug, Plasma Transfusions Show Promise in Treating CoronavirusHow to Dispel Your Child's Fears About the New CoronavirusCholesterol Drugs Might Help Curb 'High-Risk' Prostate CancersCoronavirus Spreads Most Easily When Patients Are Sickest: CDCWill Brushing and Flossing Protect You Against Stroke?Young Black Adults More Prone to Stroke, but Don't Know ItAHA News: Stroke Rates Down for Mexican Americans, Up for White AdultsCoronavirus Cases, Deaths Rise Sharply, While 2 New Cases Reported in U.S.Scientists Spot Antibody That Might Help Diagnose, Treat Autoimmune DisordersCoronavirus in America: Keep Your Panic in CheckCoronavirus Spread Slows, But Death Toll Jumps to 1,113Growing Up in U.S. 'Stroke Belt' Bad for the Brain Later in LifeShingles Vaccine Bonus: Reduced Risk of Stroke?Air Pollution Made in One State Can Cause Deaths in OthersWere You Born in an H1N1 Flu Year or an H3N2? It MattersStricter Clean Air Laws Could Save Thousands of Lives a Year: StudyCoronavirus Fears Have U.S. Pharmacies Running Out of Face MasksCoronavirus Death Toll Tops 1,000, While 13th U.S. Case ConfirmedMeds May Not Prevent Migraines in KidsHigh Testosterone Levels Have Different Health Impact for Men and WomenCoronavirus Cases Top 40,000, While Deaths Hit 908With Macular Degeneration, 1 Missed Visit to Eye Doc Can Mean Vision LossHundreds Suspected, 12 Confirmed: How CDC Identified U.S. Coronavirus CasesFor Patients on Blood Thinners, GI Bleeding May Signal Colon Cancer: StudyStudy Finds 'No Clear Rationale' for 45% of Antibiotic PrescriptionsThere's a Virus Spreading in U.S. That's Killed 10,000: The FluSome U.S. Workers Are Bringing Toxins Home to Their KidsAHA News: Expert Heart Advice for Rare Genetic Muscle Disorder9/11 Study Shows PTSD Tied to Earlier DeathWorkers With Cluster Headaches Take Twice as Many Sick DaysMore Americans to Be Evacuated From China; 12th Coronavirus Case ReportedYoung-Onset Parkinson's May Start in the Womb, New Research SuggestsHealthy Habits Can Slide After Starting Heart Medications
Questions and AnswersLinks
Related Topics

Diabetes

NFL Retirees Help Scientists Develop Early Test for Brain Condition CTE

HealthDay News
by By E.J. MundellHealthDay Reporter
Updated: Apr 10th 2019

new article illustration

WEDNESDAY, April 10, 2019 (HealthDay News) -- When NFL legend Frank Gifford died in 2015 at the age of 84, his family revealed that for years he'd suffered from mental issues caused by chronic traumatic encephalopathy (CTE), tied to head trauma experienced during his years of play.

CTE was also thought to contribute to the suicide of retired NFL great Junior Seau at the age of 43.

But there's long been one tough issue with CTE: It can only be diagnosed after death by brain autopsy.

Now, research involving retired NFL players might change all that.

The findings are preliminary, but in a report published online April 10 in the New England Journal of Medicine, researchers said they believe high-tech brain scans might someday be used to spot CTE in people while they are still alive.

That could greatly speed research into the devastating condition.

"Detection of the disease during life could be used to assess its epidemiology, risk factors and course, and could be used in treatment and prevention trials," wrote a team led by Dr. Robert Stern of Boston University School of Medicine.

One emergency medicine expert who's worked closely with pro athletes -- including players with the New York Jets -- agreed that such a test is urgently needed.

"A noninvasive way to diagnose CTE while living would allow us to treat it sooner and hopefully minimize or alter the devastating course of the disease," explained Dr. Robert Glatter, who practices at Lenox Hill Hospital in New York City.

Glatter wasn't involved in the new research, which was funded in part by Avid Radiopharmaceuticals, the company that is developing the new test.

As Stern's team explained, CTE is strongly tied to repeated head injuries in sports, such as football or boxing, and is characterized by the buildup in the brain of a protein called tau.

In prior studies of former American football players, "the number of years of tackle football experience has been associated with the severity of tau deposition" in the brain, the researchers said. But so far, clear evidence of CTE has only been available through examination of brain tissue after death.

The Boston team wondered if a high-tech form of positron-emission tomography (PET) scan might be able to spot CTE-linked tau in the brains of living people.

To find out, they had 26 retired NFL pros who'd shown signs of cognitive (thinking), mood or behavioral issues undergo PET scans. Those scans were compared to scans from men without any history of traumatic brain injury or mental health issues. All of the men were between the ages of 40 and 69.

The study found clear patterns on the scans that seemed to separate the former players from the men in the "control" group. Specifically, the NFL players at risk of CTE had elevated levels of tau protein in three key brain areas that was not seen in men without a history of head injury.

These were the same three brain regions that showed changes characteristic of CTE during postmortem autopsies, Stern's team noted.

The scans were also able to distinguish possible CTE-linked brain abnormalities from those of Alzheimer's disease, another illness closely tied to tau deposits.

Still, the study group was small and this research is in its early stages, Stern's group stressed.

"Further studies are needed to determine whether elevated CTE-associated tau can be detected in individual [living] persons," the study authors concluded.

Dr. Jamie Ullman is director for neurotrauma at North Shore University Hospital in Manhasset, N.Y. She agreed that the study "is promising in terms of identifying the utility of PET scanning to potentially diagnose cases of CTE," but "more research is, of course, needed."

For his part, Glatter said early detection would be crucial to patient care.

"Designing an accurate and reliable method to definitively diagnose the disease in those who are living is vital, because early detection may improve the chances of successful treatment if a viable approach is determined," Glatter said.

"While the study is small, the findings are encouraging and suggest that PET scans may have the ability to detect CTE in living individuals," he added.

More information

The Concussion Legacy Foundation offers more on CTE.