24-Hour Crisis Hotline: (877)SAFEGBC or (877)723-3422 Mental Health & Substance Abuse Issues

6502 Nursery Drive, Suite 100
Victoria, TX 77904
(361)575-0611
(800)421-8825
Fax: (361)578-5500

Medical Disorders
Resources
Basic InformationLookupsLatest News
Health Tip: Understanding Color BlindnessCould Profit Be a Factor in Kidney Transplant Decisions?Could Daily Low-Dose Aspirin Still Help Some People?Health Tip: Relieving Itchy SkinExperts' Guide to Trampoline SafetyHow to Keep Your Feet on a Sound, Pain-Free FootingMost Cyclists Suffering Head Injuries Not Wearing Helmets: StudyLinks Between Smog, 2nd Pregnancies and Preterm BirthHeartburn Drug Zantac May Contain Small Amounts of Known Carcinogen, FDA SaysCDC Revises Number of Vaping-Linked Lung Illnesses to 380 in 36 StatesKidney Transplants Safe When Donors Had Hepatitis CLung Cancer Screening Can Detect Other Smoking IllsIs Your State One of the 'Most Obese' in America?How to Keep Your Bones Strong and Prevent FracturesHeart Attack Can Be More Lethal If Symptoms Are More GradualHealth Tip: Understanding MononucleosisNew Strain of Strep Causing Cases of Scarlet FeverHow to Fight Hidden Causes of InflammationFDA Approves First Treatment for ILD With Systemic Sclerosis, SclerodermaOccasional Naps Do a Heart Good, Swiss Study FindsA 'Supercool' Breakthrough for Patients Awaiting Liver TransplantTreatment for Very-Preterm Infants May Lead to Antibiotic ResistanceWhy Weight Gain Often Comes With AgeNew Prosthetic Leg Can Feel Touch, Reduce 'Phantom Limb' PainThe Alexander Technique: What Could It Do for You?Drink Coffee, Avoid Gallstones?Dark Skin No Protection Against Sun's Harmful RaysSome People Vaccinated Against Mumps May Not Be Protected: StudyDiabetes Control Has Stalled Across U.S.Vaping-Linked Lung Illnesses Double, Vitamin E Acetate Leading Suspect'First Responders' on 9/11 Face Lingering Heart Woes, Study FindsHealth Officials Close in on Culprit in Vaping Lung Injury CasesGoing Vegetarian Good for Your Heart, But May Up Stroke RiskEven Small Improvements in Cholesterol, Blood Pressure Help Prevent Heart AttackHealth Tip: Signs of GallstonesHigh Post-Hospital Death Rate Trails Ebola SurvivorsClues to Why Epileptic Seizures Can Halt BreathingWhat Works Best Against Varicose Veins?Poor Circulation in Legs? Statin Meds Can Keep You Living LongerHurricane Dorian Can Wreak Havoc on Heart HealthMore CT, MRI Scans Being Used, Despite Calls to Cut BackDrop the Pop: Soda Tied to Higher Risk of Early DeathCould You Be Having a Heart Attack?Body's Natural Chemicals May Help Protect 9/11 Responders' Health: StudyObese Teen Boys More Prone to Heart Attacks in Middle AgeWeight-Loss Surgery Drops Heart Disease, Death Risk for DiabeticsHealth Tip: Managing a Poison Ivy RashFor Men, Living Alone May Mean Poorer Control of Blood-Thinning MedsLifestyle May Matter More Than Your Genes in Early Heart DiseaseAfter Heart Attack, Stenting More Than the Blocked Artery May Be Best
Questions and AnswersLinks
Related Topics

Diabetes

New Gene Variants for Type 2 Diabetes Found

HealthDay News
by -- Robert Preidt
Updated: May 23rd 2019

new article illustration

THURSDAY, May 23, 2019 (HealthDay News) -- It has long been known that lifestyle affects a person's risk of developing type 2 diabetes. Now, researchers report that they have identified rare variants of four genes that may also play a part.

For the study, an international team of scientists analyzed protein-coding genes from nearly 21,000 people with type 2 diabetes and 25,000 people without diabetes across a range of ethnicities. That included people of European, African American, Hispanic/Latino, East Asian and South Asian ancestries.

The genes identified in the study and the proteins they encode are potential targets for new diabetes medicines, and may help improve understanding and treatment of the disease, according to the study authors.

In addition, the data suggests that hundreds more genes linked with diabetes will be identified in the future, the researchers said.

"These results demonstrate the importance of studying large samples of individuals from a wide range of ancestries," said senior study author Michael Boehnke. He is director of the Center for Statistical Genetics at the University of Michigan School of Public Health, in Ann Arbor.

"Most large population studies focus on individuals of European ancestry, and that can make it hard to generalize the results globally. The more diverse the cohort makes for better, more informative science," Boehnke explained in a university news release.

Study first author Jason Flannick added, "We now have an updated picture of the role of rare DNA variations in diabetes." Flannick is an assistant professor of pediatrics at Harvard Medical School, and the division of genetics and genomics at Boston Children's Hospital.

"These rare variants potentially provide a much more valuable resource for drug development than previously thought. We can actually detect evidence of their disease association in many genes that could be targeted by new medications or studied to understand the fundamental processes underlying disease," Flannick explained in the news release.

More than 400 million people worldwide have diabetes, and most of those cases are type 2, according to the World Health Organization. Diabetes is believed to be the seventh leading cause of death worldwide.

The study was published May 22 in the journal Nature. The findings are publicly available online through the Type 2 Diabetes Knowledge Portal, which means scientists worldwide can access and use them in their own research.

More information

The American Diabetes Association has more on type 2 diabetes.