24-Hour Crisis Hotline: (877)SAFEGBC or (877)723-3422 Mental Health & Substance Abuse Issues

6502 Nursery Drive, Suite 100
Victoria, TX 77904
(361)575-0611
(800)421-8825
Fax: (361)578-5500

Child & Adolescent Development: Overview
Resources
Basic InformationMore InformationLatest News
Why Are Fewer U.S. Kids Going to Pediatricians?Severe Deprivation in Childhood Has Lasting Impact on Brain SizeHealth Tip: What Your Child Can do About BullyingWildfires Send Kids to ERs for Breathing ProblemsTV Can Be a Good Influence on Kids' Eating HabitsWould Tighter Swimming Rules at Public Beaches, Lakes and Rivers Save Lives?U.S. Doctors Often Test, Treat Kids UnnecessarilyHealth Tip: Safety Steps if Your Child is Home AloneHealth Tip: Help Your Child Safely Lose WeightAmericans Need to Tackle Youth Obesity: U.S. Task ForceGenes, Family Are Key Predictors of School SuccessKids' 'Microbiome' May Play Key Role in AsthmaA Puppy in Santa's Sack? Probably Not, Say ParentsMore Kids, Teens Landing in ERs After Opioid OverdosesGetting Active Helps Kids' Hearts, Even in the ObeseWhen Does Your Child's Flu Merit an ER Visit?Health Tip: Managing Hearing Loss in ChildrenHealth Tip: Is My Child Too Sick to Go to School?Differences Found in Brains of Kids Born to Depressed ParentsSecondhand Smoke Starts Kids on Path to Heart Disease: StudyHealth Tip: Choosing a PediatricianMany Kids Traveling Overseas Aren't Vaccinated Against MeaslesCould Obesity Alter a Child's Brain Structure?Dramatic Rise in Eye Injuries From BB and Paintball GunsTwo-Thirds of Child Abuse Survivors Do Well as AdultsAHA News: Serious Heart Defects Increase Heart Failure Risk in Early AdulthoodMore U.S. Kids Are Shunning Sweetened DrinksAs Disease Outbreaks Tied to 'Anti-Vaxxers' Rise, States Take Action'Don't Give Up:' Parents' Intuition Spots a Rare Illness Before Doctors DoFDA Approves First Contact Lens That Slows Myopia ProgressionStereotypes About Girls and Math Don't Add Up, Scans ShowStudies Confirm HPV Shot Is SafeThese Sports Are Most Likely to Send Young Americans to the ERNature Nurtures KidsClimate Change Will Hurt Kids Most, Report WarnsTough Childhoods Can Leave a Lifetime of Harm, Experts SayMany U.S. Parents Can't Find a Psychiatrist to Help Their ChildAnti-Vaxxers Find Ways Around States' 'Personal Exemption' BansMake a Plan for Gardening Next Spring With Your KidsCheck Those Halloween Treats So They're Safe to EatFast-Food Outlet in Neighborhood Could Mean Heavier Kids: StudyAntihistamines Linked to Delayed Care for Severe Allergic Reaction: StudyPain Twice as Common for Kids With Autism: StudyPediatricians' Group Calls for More Research on Artificial SweetenersExperts Support Weight-Loss Surgery for Very Obese KidsHalloween Can Be Frightful for Kids With Allergies, AsthmaLawn Mowers May Be Even More Dangerous for Rural KidsHow Young Is Too Young to Leave Kids Home Alone?Skiing, Snowboarding Injuries Most Severe Among Younger KidsKids' Trampoline Injuries Take Another Bounce Upwards
Questions and AnswersLinks
Related Topics

ADHD: Attention Deficit Hyperactivity Disorder
Childhood Mental Disorders and Illnesses
Child Development & Parenting: Infants (0-2)
Child Development & Parenting: Early (3-7)

How Do Birth Defects Affect Childhood Cancer Risk?

HealthDay News
by -- Robert Preidt
Updated: Jun 20th 2019

new article illustration

THURSDAY, June 20, 2019 (HealthDay News) -- Children with birth defects may be at increased risk for childhood cancer, a new study finds.

Researchers analyzed data from more than 10 million children born in Texas, Arkansas, Michigan and North Carolina between 1992 and 2013.

Compared to children without a birth defect, those with genetic defects were almost 12 times more likely to develop cancer by age 18. Those whose birth defect had no known genetic cause -- also known as non-chromosomal defects -- had more than 2.5 times the risk.

Types of cancer that were more frequent in children with non-chromosomal birth defects included hepatoblastoma, a form of liver cancer, and neuroblastoma, which often starts in the adrenal glands.

Children with more than one non-chromosomal defect had a greater risk of cancer than those with one such defect, according to the study.

Scientists from Baylor College of Medicine in Houston led the investigation. It was described as the largest ever to evaluate cancer risk in children with birth defects.

"While cancer risk in children with certain chromosomal defects like Down syndrome is well-established, much less is known for children with birth defects where there is no known genetic cause," said researcher Philip Lupo, an associate professor of pediatrics/hematology-oncology.

"Non-chromosomal defects, as a group, affect more children, but one of the primary challenges of understanding risk among these children is that limited sample sizes make studying specific defects, like spina bifida, more difficult," he said in a college news release.

Postdoctoral associate Jeremy Schraw said the research had two aims.

"Our two key objectives in this study were to identify children who are at an increased risk for cancer, because subsets of these children may one day benefit from screening and better clinical management, and to uncover clues as to why cancer occurs more frequently in this population," Schraw said.

"These findings solidify our understanding of cancer risk in these children and show that we need additional research in this area," he added.

While the study found a strong link between birth defects and cancer risk, Schraw said it's important to remember that both birth defects and childhood cancers are rare.

The next goal is now in focus, researchers said.

"In the future, we hope to identify the specific genes behind these associations and systematically research what happens from the time of birth to the time of cancer onset to also understand if environmental factors may be contributing to cancer development," Lupo said.

The study was published recently in the journal JAMA Oncology.

More information

The American Cancer Society has more on cancer in children.