24-Hour Crisis Hotline: (877)SAFEGBC or (877)723-3422 Mental Health & Substance Abuse Issues

6502 Nursery Drive, Suite 100
Victoria, TX 77904
Fax: (361)578-5500

Medical Disorders
Basic InformationLookupsLatest News
FDA Approves First Oral Drug for Spinal Muscular AtrophyCOVID-19 Fears Stop Americans From Seeking Help for Heart EmergenciesAHA News: What Do Heart Patients Need to Know About COVID-19 Now?Have Diabetes? Don't Lose Sight of Danger to Your EyesBlood Test Might Spot Most Dangerous COVID-19 CasesAs Schools Reopen, Report Shows 97,000 U.S. Kids Infected With COVID in Late JulyWhat Parents Need to Know About Teens and ConcussionsBaby's Meningitis Case Highlights Growing Danger of Antibiotic ResistanceAs in Adults, Minority Kids Hit Hardest by COVID-19Simple Test Shows Which Face Masks Are BestBeware of Hand Sanitizers Containing MethanolWhat Athletes Should Know About COVID-19, Heart Damage and Working OutCOVID-19 Causing More Stress in America Than Other Nations: SurveyWill Your Kid Play School Sports This Fall? Here's Some Guidance on Doing It SafelyScientists Call for Broader Use of Faster COVID TestsTwo Common Nutrients Might Keep Vertigo at BayPeople Are Dying, Going Blind After Drinking Hand Sanitizer, CDC WarnsMore Social Media Use, More Fake COVID NewsSkip the 'Maskne,' Not the MaskObesity Ups Odds for Severe COVID-19, But Age MattersSeven States Join Pact to Speed Coronavirus TestingStudy Casts Doubt on Value of Cholesterol DrugsCOVID-19 Fears Had Sick, Injured Americans Avoiding ERsCancer Diagnoses Plunge as Americans Avoid Screening During PandemicMysterious Paralyzing Illness in Kids Is Set to Return, CDC WarnsMany Older Americans Staying Strong in the PandemicCoronavirus Cases Now Climbing in the MidwestCould the First Drug That Slows Arthritis Be Here?Schools Can Reopen Safely If Precautions in Place, Australian Study ShowsFace Masks, Yes, But Don't Forget Hand-Washing TooEven With PPE, Risk of COVID-19 Still High for Frontline WorkersCoronavirus Pandemic Becoming Far More Widespread, Birx SaysGuard Against Lyme Disease This SummerKids 'Efficient' Transmitters as COVID-19 Raced Through a Georgia Summer CampCollege Students Will Need COVID Tests Every 2-3 Days for Campus Safety: StudyAHA News: Sustained High Blood Pressure May Damage Brain VesselsAnother Side Effect of COVID-19 -- Lasting Hearing Problems?Pandemic Could Complicate Hurricane SeasonStudy Reveals How Coronavirus Travels IndoorsNew Study Sheds Doubt on Notion Kids Aren't COVID-19 SpreadersAHA News: Are Virtual Doctor Visits Safe for Discharged Heart Failure Patients?Double Lung Transplants Save Lives of Sickest COVID PatientsGynecological Cancers Not a Risk for Severe COVID-19: Study11 States Could Face ICU Doc Shortages as Coronavirus Cases SurgeWildfire Pollution Puts Kidney Patients at RiskAmerica's Progress Against Early Cardiovascular Death Is SlowingAHA News: 5 Easy Ways to Keep Tabs on Heart HealthGene Study Shows How Coronavirus Swept Through the Diamond PrincessOne Disease Mosquitoes Don't Spread: CoronavirusU.S. Coronavirus Death Toll Surges Past 150,000
Questions and AnswersLinks
Related Topics


New Strain of Strep Causing Cases of Scarlet Fever

HealthDay News
by By Steven Reinberg
HealthDay Reporter
Updated: Sep 11th 2019

new article illustration

TUESDAY, Sept. 10, 2019 (HealthDay News) -- A new, more toxic strain of strep A bacteria is causing an outbreak of scarlet fever among British children, researchers report.

The upswing in scarlet fever is the biggest seen since the 1960s. Between 2014 and 2016, the number of cases went from 15,000 to more than 19,000. The infection tends to peak between March and May, the study found.

"The new lineage [of strep A] seems to be outcompeting its predecessor within the population," said lead researcher Dr. Shiranee Sriskandan, a professor of infectious diseases at Imperial College London.

This new strain also appears to produce more toxin than the previous strain, she said.

Scarlet fever is easily cured with antibiotics, especially penicillin, according to Dr. Marc Siegel, a professor of medicine at NYU Langone Medical Center in New York City.

If strep infections are not treated, however, they can spread throughout the body and become fatal, he said.

"There are 11,000 to 15,000 cases of invasive strep among kids each year in the United States, which result in up to 1,500 deaths," Siegel said.

He fully expects this more aggressive strain of strep A to show up in the United States.

Sriskandan added that "this strain type is fully sensitive to commonly used antibiotics, so resistance has not played a part in its emergence."

Strep A causes infections other than scarlet fever, and some of these are also on the rise in the United Kingdom, Sriskandan said.

Strep infection causes sore throat, fever, swelling lymph nodes and congestion. With scarlet fever, there's also a body rash.

Siegel advises parents whose kids may be suffering from strep to see their pediatrician and get them tested and treated with antibiotics if needed.

For the study, Sriskandan and her colleagues looked at the type of "emm gene" in the Strep A that was causing cases of scarlet fever.

The investigators found that the increase in scarlet fever in London in 2014 was linked to strep A types emm3 and emm4. During the spring of 2015 and 2016, however, throat infections were tied to emm1 strains.

In 2014, only 5% of the infections were emm1, but by 2015 that had risen to 19% and by 2016 to 33%, the researchers found.

The emm1 strain also became the dominant strain involved in other strep A infections, increasing to 42% of strep infections by 2016, the findings showed.

An analysis of the genetics of the emm1 strain uncovered 27 mutations in the 2015 and 2016 strains, which increased the production of the toxin streptococcal pyrogenic exotoxin -- that's responsible for making people ill with scarlet fever and other infections.

This mutated strain, called M1UK, makes nine times more toxin than other emm1 strains, Sriskandan said. It's the strain that was found in 84% of all the emm1 genomes analyzed in England and Wales, she noted.

The researchers then compared the M1UK strains with 2,800 strains from around the world, and although M1UK was unique, strains from Denmark and the United States also showed bits of M1UK.

"The strep A strains that cause throat infections and scarlet fever are essentially the same as those that cause the rarer invasive infections -- increases in the former infections may lead to increases in the rarer infections," Sriskandan said.

A vaccine against strep A would go a long way to prevent all of these infections and would also reduce conditions that result from strep infections, such as rheumatic heart disease, she added.

Dr. Marcelo Laufer is a pediatric infectious disease specialist at Nicklaus Children's Hospital in Miami. He said, "Strep doesn't change much, which is why it's still susceptible to penicillin."

What happens is that it attacks different body systems, so some diseases caused by strep peak while others ebb in an ever-changing pattern, he said.

"Strep has different mechanisms of disease -- sometimes it's invading, sometimes it's by toxin production and sometimes by fooling the body to react to it, like rheumatic fever," Laufer said.

It's the changing nature of the same bacteria that makes it so challenging, he explained. "It's peaks and valleys of the same disease in different forms."

The report was published online Sept. 10 in The Lancet Infectious Diseases journal.

More information

For more on scarlet fever, head to the U.S. Centers for Disease Control and Prevention.