24-Hour Crisis Hotline: (877)SAFEGBC or (877)723-3422 Mental Health & Substance Abuse Issues

6502 Nursery Drive, Suite 100
Victoria, TX 77904
(361)575-0611
(800)421-8825
Fax: (361)578-5500

Medical Disorders
Resources
Basic InformationLookupsLatest News
Health Tip: Signs of Food PoisoningSepsis Causes Far More Deaths Worldwide Than ThoughtMillennials Most Likely to Skip Flu Shot, Believe 'Anti-Vaxxer' Claims: PollResearchers Alter Mosquitoes to Resist Dengue InfectionMany Americans Are Inactive, With Southerners Faring WorseVirtual Reality Can Bring Real-Life PainAre Doctors Discarding 'Injured' Kidneys That Might Be Used for Transplant?Nerve Stimulation Therapy Could Cut Fibromyalgia PainWhich Obesity Surgery Is Right for You?Brake Dust Another Driver of Air PollutionWhat Works Best to Help Men With Overactive Bladder?More Studies Link Vaping to Asthma, COPDCertain Diabetes Meds May Lower Gout Risk, TooHeart Transplants From Donors With Hepatitis C May Be Safe: StudyClimate Change May Translate Into More Fatal InjuriesAll in the Timing: Many Get Knee Replacement Too Late or Too SoonHealth Tip: Preparing for an UltrasoundLow Levels of Key Blood Cells Could Signal Higher Death RiskGyms Are Fertile Ground for GermsTwo More Heartburn Meds Recalled Due to Possible CarcinogenZika Damage Showing Up in Babies Deemed 'Normal' at BirthHealth Tip: Coping With Winter NosebleedsHeart Disease May Up Risk of Kidney FailureFlu Cases Surge Early, Could a Tough Season Lie Ahead?Cluster of Unhealthy Risk Factors Could Raise Odds of Recurrent Blood ClotsAHA News: Worried About Dementia? Check This Blood Pressure NumberNew Study Reports Alarming Surge in E-Scooter AccidentsSo Long, 98.6: Average Human Body Temperature Is DroppingWhat Matters More for Obesity Risk, Genes or Lifestyle?Health Tip: Protect Yourself From Household ChemicalsOzone, Wood Smoke Raise Odds of COPD in Smokers and NonsmokersSmog May Be Bad for Your BonesEver Get a Rash from Your Skin Cream or Makeup? Here's WhyHealth Tip: 5 Eye Myths DebunkedHealth Tip: Allergic Reaction First AidTB Vaccine More Powerful When Given IntravenouslyGene Therapy May Be Long-Term Cure for Type of HemophiliaClots in Space: Astronaut's Blocked Vein Brings Medical InsightHealth Tip: Help Your Child Safely Lose WeightPatients Often Bring Undetected 'Superbug' to the Hospital: StudyExperimental Drug Could Be New Option Against ArthritisBanned for Decades, DDT and Dioxins Are Still Harming U.S. BabiesHealth Tip: When Bruising is a Red FlagAmericans Need to Tackle Youth Obesity: U.S. Task ForceFestive Foods Can Leave Those on Restricted Diets Out in the ColdHow You Can Be Overfat Without Being OverweightSleep Disturbances May Trigger MigraineOlder Blood Safe as New Blood for TransfusionsHealth Tip: Home Care for Stomach CrampsCould You Be Allergic to Additives?
Questions and AnswersLinks
Related Topics

Diabetes

Tiny Genetic Tweak May Stop Ebola Virus in Its Tracks

HealthDay News
by -- Steven Reinberg
Updated: Sep 18th 2019

new article illustration

WEDNESDAY, Sept. 18, 2019 (HealthDay News) -- New experiments in monkeys suggest that one slight alteration to the DNA of the Ebola virus might render it harmless to humans.

Changing just a single protein appears to activate the body's immune system to fight off the deadly infection, researchers report.

The mutated virus also acts like a vaccine that protects the animals from becoming infected, they added.

For the study, a team of scientists changed a protein in the virus called VP35, which allows the Ebola to block any early immune responses to infection.

This mutated form of the virus was not only safe for researchers to work with, it also induced an immune response that protected monkeys exposed to Ebola from getting sick.

"We think that VP35 is affecting immune responses overall, so after giving this virus that doesn't cause disease, we thought maybe it will protect animals if you challenge them with the wildtype Ebola virus," said senior study author Christopher Basler. He is director of the Center for Microbial Pathogenesis at Georgia State University.

"They were completely protected. None of them showed any sign of disease to the parental virus," Basler said in a university news release.

"The big take-home message is that we can make an Ebola virus that grows, but if we disable this function, we can now make a virus that is very highly attenuated in the animals," he explained.

The goal of the research is to see if this approach can be used in a drug that can knock out the VP35 protein in Ebola and protect people, researchers said, although research on animals may not produce the same results in humans.

Also, targeting this protein might be useful in producing an immune response to similar diseases like the Marburg virus, Basler said.

The report was published Sept. 17 in the journal Cell Reports.

Ebola is a deadly virus that causes outbreaks of severe disease in humans. From 2013 to 2016, an epidemic that began in West Africa affected more than 28,000 people, killing more than 11,000. An outbreak that began in the Democratic Republic of the Congo in 2018 has already killed nearly 1,800 people, the researchers added.

More information

For more on Ebola, head to the U.S. Centers for Disease Control and Prevention.