24-Hour Crisis Hotline: (877)SAFEGBC or (877)723-3422 Mental Health & Substance Abuse Issues

6502 Nursery Drive, Suite 100
Victoria, TX 77904
(361)575-0611
(800)421-8825
Fax: (361)578-5500

Alzheimers Disease and other Cognitive Disorders
Resources
Basic Information
Introduction & Causes of Cognitive DisordersDementiaAlzheimer's DiseaseOther Cognitive DisordersDementia Coping Skills & Behavior ManagementTraumatic Brain Injury (TBI)Conclusion and Resources
More InformationLatest News
How to Ease Loved Ones With Alzheimer's Through the PandemicCaring for Dementia Patient During Pandemic? Try These Stress-Busting TipsDirty Air Might Raise Your Odds for DementiaRecovery From Mild Brain Trauma Takes Longer Than Expected: StudyCould Sleep Apnea Put You at Risk for Alzheimer's?Daily Aspirin Won't Stop Dementia, Study FindsStudy Ties Brain Inflammation to Several Types of DementiaHeart Drug Combos Might Also Lower Your Dementia Risk: StudyU.S. Primary Care Docs Unprepared for Surge in Alzheimer's CasesMaria Shriver Sounds the Alarm on Women and Alzheimer'sTraumatic Brain Injuries Raise Risk of Psychiatric Ills in SoldiersGrowing Up in U.S. 'Stroke Belt' Bad for the Brain Later in LifeTwo Experimental Drugs Disappoint With Inherited Alzheimer'sGene Variant Ups Dementia Risk in Parkinson's Patients: StudyGene Variation May Protect Against Alzheimer's: StudyWhen Dementia Harms Speech, Native Language MattersEven 1 Night's Bad Sleep Can Raise Levels of a Brain 'Marker' for Alzheimer'sAHA News: Worried About Dementia? Check This Blood Pressure NumberStudy Might Point Alzheimer's Research in Whole New DirectionMore Doubt That Plaques in the Brain Cause Alzheimer'sObesity in Middle Age Could Raise Odds for Alzheimer's LaterCan Air Pollution Take a Toll on Your Memory?Animal Study Offers Hope for Treating Traumatic Brain InjuriesAlmost Half of Older Americans Fear Dementia, Try Untested Ways to Fight ItPeople Who Can't Read Face 2-3 Times Higher Dementia RiskEducation a Buffer Against Alzheimer's Among Blacks: StudyDown Syndrome Carries Raised Risk of Dementia by 55A Gene Kept One Woman From Developing Alzheimer's -- Could It Help Others?Number of Americans With Dementia Will Double by 2040: ReportIs Head Injury Causing Dementia? MRI Might ShowBanned Trans Fats Linked to Higher Dementia Risk: StudyFamily Can Help Keep Delirium at Bay After SurgeryPro Soccer Players More Likely to Develop Dementia: StudyDrug Limits Damage of Brain InjuryYour Personality as a Teen May Predict Your Risk of DementiaWhat Helps Calm Agitated Dementia Patients?AHA News: Growing – and Aging – Hispanic Population at Risk for DementiaAHA News: Yo-Yoing Blood Pressure Could Be Bad for Those With Alzheimer'sGive Seniors a Memory Check at Annual Checkups, Experts SayFor People at High Risk, Evidence That Exercise Might Slow Alzheimer'sDementia Caregivers Often Face Sleepless NightsHealth Tip: Dementia and DrivingGetting Hitched Might Lower Your Odds for DementiaHow You Can Help Head Off Alzheimer's DiseaseDeep Brain 'Zap' Restores Vivid Memories to Alzheimer's PatientsHow to Protect a Loved One With Dementia During a Heat WaveToo Much Napping May Signal Alzheimer'sDepression, Alzheimer's Might Be Part of Same Process in Some Aging Brains: StudyStay Social to Help Cut Your Odds of DementiaBlood Test May Spot Brain Changes of Early Alzheimer's
Questions and AnswersLinks
Related Topics

Gene Variant Ups Dementia Risk in Parkinson's Patients: Study

HealthDay News
by -- Robert Preidt
Updated: Feb 6th 2020

new article illustration

THURSDAY, Feb. 6, 2020 (HealthDay News) -- A genetic variant associated with Alzheimer's disease increases the risk of dementia in people with Parkinson's disease, researchers say.

The finding could lead to new treatments for dementia in Parkinson's patients, according to the team at Washington University School of Medicine in St. Louis.

Parkinson's disease is a progressive neurological disorder that causes tremors, stiffness, slow movement and impaired balance.

Eighty percent of patients diagnosed with Parkinson's develop dementia within 20 years. Those who carry a particular variant of the gene APOE have an especially high risk, the study authors said.

The researchers found that Parkinson's-related proteins spread more rapidly through the brains of mice with the high-risk APOE4 variant, and that memory and thinking skills decline faster in Parkinson's patients who have the variant.

APOE4 is known to increase the risk of Alzheimer's disease by three to five times.

The study was published Feb. 5 in the journal Science Translational Medicine.

"Dementia takes a huge toll on people with Parkinson's and their caregivers," said lead author Dr. Albert Davis, an assistant professor of neurology. "The development of dementia is often what determines whether someone with Parkinson's is able to remain in their home or has to go into a nursing home."

These findings could lead to therapies that target APOE to slow or prevent mental decline in people with Parkinson's, the study authors said in a university news release.

About 930,000 people in the United States have Parkinson's disease, which is believed to be caused by a buildup of toxic proteins called alpha-synuclein in a brain area involved in movement. The protein clumps damage and can kill brain cells.

"Parkinson's is the most common, but there are other, rarer diseases that also are caused by alpha-synuclein aggregation and also have very limited treatment options," Davis said. "Targeting APOE with therapeutics might be a way to change the course of such diseases."

Davis noted that APOE doesn't affect the overall risk of developing Parkinson's or its progression, so an APOE-targeted therapy might slow or prevent dementia without improving movement problems. Even so, such therapy could be beneficial, he suggested.

"Once people with Parkinson's develop dementia, the financial and emotional costs to them and their families are just enormous," Davis said. "If we can reduce their risk of dementia, we could dramatically improve their quality of life."

More information

The Parkinson's Foundation has more on Parkinson's disease.