24-Hour Crisis Hotline: (877)SAFEGBC or (877)723-3422 Mental Health & Substance Abuse Issues

6502 Nursery Drive, Suite 100
Victoria, TX 77904
(361)575-0611
(800)421-8825
Fax: (361)578-5500

Medical Disorders
Resources
Basic InformationLookupsLatest News
Could the Pill Reduce Asthma Attacks?Coronavirus Most Contagious Soon After InfectionPeople Should Know That COVID Vaccine Might Spur Transient Sickness: CDC ExpertsAnother Study Finds COVID Usually Mild in KidsBlacks, Hispanics Account for More Than Half of COVID Deaths: StudyCollege Kid Coming Home for Thanksgiving? Here's How to Keep Your Family SafeParents' Age Key to Whether Kids Get Vaccinated Against COVID, Study FindsVegan Diets Tied to Higher Bone Fracture RiskThird COVID Vaccine Shows Effectiveness; FDA Approves New TreatmentWhich Kids With COVID Will Get Very Sick?Add Kids to COVID Vaccine Trials, Pediatricians' Group SaysLosing Your Hair Because of Pandemic Stress?How Hospitals Can Cut Patients' FallsMany Young Americans Lonely, Depressed During Pandemic: SurveyWHO Says No to Remdesivir as COVID-19 TreatmentBirx Says U.S. COVID Cases Are Skyrocketing as Holidays ApproachA 'Stunning' Alternative Rx for Arthritic Joints?Are Statin Side Effects 'All in Your Head'?Stay Home This Holiday, CDC and Medical Groups UrgeDirty Air Endangers Homeless People: StudyU.S. Coronavirus Deaths Top a Quarter MillionOxford COVID Vaccine Safe, Effective, Especially in Older AdultsAre High-Dose Blood Thinners Needed for Severe COVID-19?Childhood Lead Exposure Tied to Brain Changes in Middle AgeWith Cold Weather Forcing Patrons Inside, How Safe Are Restaurants?AHA News: Fauci Offers a COVID-19 Lesson and Looks to the Future'A Struggle:' Physical, Mental Ills Can Linger Months After COVID RecoveryExoskeleton Helps Paralyzed People Walk AgainAre You Feeling 'Pandemic Fatigue'?Chinese COVID Vaccine Appears Safe, EffectiveFDA Approves First Rapid COVID Test for Home UseCould Night Shifts Raise Asthma Risk?AHA News: Black, Hispanic People Hospitalized for COVID-19 at Disproportionately High RatesAHA News: COVID-19 Patients of All Ages With Obesity Face Higher Risk of Complications, DeathOverweight With Arthritic Knees? You Might Want to Avoid TennisAnswers to Your Questions About Face MasksHow to Be a Living Liver DonorCoronavirus Immunity Might Last at Least 6 MonthsCalifornia, Iowa Toughen Restrictions as COVID Cases ClimbAllergies Won't Up Your Odds for Severe COVIDCombo 'Polypill' May Cut Heart Attack, Stroke Risk Up to 40%Restful Sleep Could Help Ward Off Heart FailureMany Americans Plan to Party Indoors, Regardless of Risk: SurveyDeadly New Ebola-Like Disease Emerges in BoliviaModerna Vaccine Shows 94.5% Effectiveness Against COVIDGlobal Warming Has Ticks Jumping From Dogs to HumansMore Evidence That Vaping Ups Lung Disease RiskAHA News: Heart Risk Factors Vary Greatly Among Asian ImmigrantsWrongly Prescribing Antibiotics Sets Dangerous PatternLarge Study Finds Blacks, Asians More Vulnerable to COVID
Questions and AnswersLinks
Related Topics

Diabetes

Combo 'Polypill' May Cut Heart Attack, Stroke Risk Up to 40%

HealthDay News
by By Dennis Thompson HealthDay Reporter
Updated: Nov 16th 2020

new article illustration


MONDAY, Nov. 16, 2020 (HealthDay News) -- A single pill loaded with cholesterol and blood pressure medications can reduce your risk of heart attack and stroke by as much as 40%, a new international study reports.

The "polypill" containing three generic blood pressure medications and a statin dramatically reduced the risk of heart-related illness in people with no prior history of heart problems, according to clinical trial results.

When taken on its own, the polypill reduced by about 20% the risk of heart attack, stroke, procedures to reopen clogged arteries and other heart disease, the researchers reported.

The polypill combined with daily low-dose aspirin was even more effective, reducing heart health problems by up to 40%, the findings showed.

"We've estimated that if even just one-half of people with high blood pressure or diabetes were treated with such a polypill, at least somewhere between 2 and 4 million premature deaths, heart attacks and strokes would be avoided every year," said lead researcher Dr. Salim Yusuf, a professor of medicine at McMaster University in Canada.

Such a polypill would have other benefits as well, Yusuf said. It would be easier for patients, who wouldn't have to juggle fistfuls of daily medications, and for doctors who'd only have to write one prescription. A single pill also is cheaper to market and distribute.

"I personally would just like to get people to use the components either separately or together. If it's more convenient together, why not?" Yusuf said.

The study results were published online Nov. 13 in the New England Journal of Medicine. For the trial, more than 5,700 people from nine countries were randomly assigned to one of four groups. They were asked to take one of the following daily: both the polypill and aspirin, the polypill alone, aspirin alone, or only a placebo.

The polypill used in this study included cholesterol-lowering simvastatin and three blood pressure meds (a beta blocker called atenolol, a diuretic called hydrochlorothiazide and an ACE inhibitor called ramipril).

Compared with placebo, the polypill successfully lowered blood pressure and cholesterol, the investigators found.

Only 4.4% of those who took the polypill alone had a heart attack, stroke, artery-reopening procedure or died of heart disease, compared to 5.5% who took the placebo. About 4.1% of those who took aspirin alone developed heart-related illness, compared to 4.7% of those with the placebo.

Combining a polypill with aspirin provided the best benefits, the study authors said.

The polypill/aspirin combination reduced heart problems and deaths by 31%, the researchers discovered. People who continued to take the pill without interruption for about four years saw a 40% reduced risk of heart problems.

"When you look at the combination of aspirin and the polypill, you definitely see a meaningful reduction in cardiovascular events," said Dr. Eugene Yang, chair-elect of the American College of Cardiology's Prevention of Cardiovascular Disease Council.

In the United States, such a polypill could be a valuable tool in protecting the heart health of people who have less access to health care, Yang said.

"With the health care disparities that exist in this country, there could be opportunities where a polypill in the United States would be beneficial," Yang said.

Currently, no such cholesterol/blood pressure polypill exists in the United States, Yusuf said.

Yang pointed out that "the fact that it's generic is a double-edged sword, because no big pharma company is willing to invest a lot of money in developing and marketing a polypill. It may require either health insurance companies or governments or charitable organizations to develop polypills."

There also might be some reluctance among doctors to prescribe a pill loaded with a number of different medications, Yang added.

"We've all been taught in medical school you need to give one drug at a time and see what it does before you add a second one," Yang said.

The study was 95% funded by charitable organizations like the Wellcome Trust UK and government agencies, Yang said. The Indian company Cadila Pharmaceuticals provided 5% of the funding, which included production and distribution of the polypills.

The researchers presented their findings over the weekend at this year's virtual meeting of the American Heart Association.

More information

Harvard Medical School has more about polypills.

SOURCES: Salim Yusuf, MD, DPhil, professor, medicine, McMaster University, Hamilton, Ontario, Canada; Eugene Yang, MD, chair-elect, American College of Cardiology's Prevention of Cardiovascular Disease Council; New England Journal of Medicine, Nov. 13, 2020, online