24-Hour Crisis Hotline: (877)SAFEGBC or (877)723-3422 Mental Health & Substance Abuse Issues

6502 Nursery Drive, Suite 100
Victoria, TX 77904
(361)575-0611
Fax: (361)578-5500
Regular Hours: M-Fri 8am - 5pm
Every 3rd Thurs of the Month - Extended Hours Until 7 pm

Child & Adolescent Development: Overview
Resources
Basic InformationMore InformationLatest News
Pandemic Putting Added Strain on Parents of Kids With CancerDogs and Kids Are 'In Sync,' Study ShowsTeachers Main Drivers of School COVID Outbreaks, So Vaccinations Needed: StudyTips to Keep Young Athletes Injury-FreeMental Illness in Childhood Could Mean Worse Physical Health Decades LaterKids' Robust Immune Systems May Shield Them From COVID-19: StudyFertility Treatments Might Affect Kids' Growth, But Not for LongMom's Heart Health While Pregnant Could Influence Her Child's Health for YearsPandemic Has Affected Kids' Dental Health: PollNew Rabies Prevention Treatment Also Works in Kids: StudyWhen Will Kids Get the COVID Vaccines?U.S. Schools Can Reopen, With Safeguards in Place: CDCFetal Surgery Is Changing Lives for Kids With Spina BifidaKids Who Got Flu Shot Had Milder COVID Symptoms: StudyVery Little Spread of Coronavirus at Kids' Day Camps: StudyWhen Kids Misbehave, 'Verbal Reasoning' Can Sometimes BackfireVaccines Saved 37 Million Lives, Mostly Children, Over Past Two DecadesAnchor It! Toppling TVs, Furniture Can Injure and Kill KidsWhy Do Black Children Get Fewer Scans When They're Seen in ERs?Pandemic May Be Affecting How Parents Feed Their KidsRace Plays Role in Kids' Food Allergies: StudyToo Many Kids With Special Needs Are Going Without Adequate SupportThere’s ‘A Path Forward’ to Reopening Schools, CDC Officials SayKids Aren't Scared by Medical Workers' PPE, Study FindsHand Sanitizer Is Harming Kids' Eyes, Often SeriouslyKids Highly Likely to Transmit Coronavirus to Others: StudyKids' ER Visits for Injuries Rose During Lockdown, While Non-Injury Cases FellShould Your Child Get a COVID Test?Climate Change Is Spurring Malnutrition in Kids WorldwideNew Year, New Tips for Keeping Your Kids Safe and HealthyAHA News: Pandemic Pods Offer Social Relief, But There Are RisksPediatricians' Group Says School Is Priority, With Proper Safety MeasuresKids With Congenital Heart Disease Face Higher Odds of Mental Health IssuesReady to Resume Sports?  Health Tips for Getting Back in the GameMasks Don't Mask Others' Emotions for KidsCould Going Vegetarian Lower Kids' Asthma Risk?Parents Feel the Strain as Pandemic Adds New Role: TeacherInvolved Dads Make a Difference for Disadvantaged TeensPoll Charts U.S. Parents' Biggest Worries During PandemicDo Genes Doom Some Kids to Obesity? Probably Not, Study FindsSchools, Day Care Not a Big Factor in Kids Getting COVID: StudyType 2 Diabetes in Youth Is Especially Unhealthy: StudyWhen Sepsis Strikes Children, Black Kids More Likely to Die: StudyNew Clues to Crohn's Disease in KidsKids With Dyslexia May Have Hidden StrengthsKids' Weight Rises When Convenience Stores Open Nearby: StudyA Better, Safer Way to Rid Some Kids of Seizures?More Clues to Why Kids Have Much Milder COVID-19Pandemic Causing Dangerous Delays in Care When Appendicitis Strikes KidsHow to Keep Kids Resilient in a Strange Holiday Season
Questions and AnswersLinks
Related Topics

ADHD: Attention Deficit Hyperactivity Disorder
Childhood Mental Disorders and Illnesses
Child Development & Parenting: Infants (0-2)
Child Development & Parenting: Early (3-7)

New Clues to Crohn's Disease in Kids

HealthDay News
by Robert Preidt
Updated: Dec 14th 2020

new article illustration

MONDAY, Dec. 14, 2020 (HealthDay News) -- Important clues about Crohn's disease in children have emerged in new research.

Scientists analyzed gene expression in individual cells in the inner lining (epithelium) of the intestines of human fetuses, six to 10 weeks after conception.

Then, they examined tissue from the intestines of 4- to 12-year-olds with Crohn's disease.

The upshot: Some of the cellular pathways active in the fetuses' intestinal lining appear to be reactivated in kids with Crohn's. This was not found in children without the inflammatory bowel disease, the investigators said.

The study, published online Dec. 7 in the journal Developmental Cell, could lead to better management and treatment of Crohn's, according to the authors.

Recent decades have seen a surge in incidence of Crohn's disease -- especially in children, who can suffer symptoms such as abdominal pain, diarrhea and fatigue.

The cause of Crohn's isn't known, treatment often fails and there is no cure, the researchers noted.

"Crohn's disease can be particularly aggressive and more treatment-resistant in children, so there's a real need to understand the condition when it affects them and perhaps come up with childhood-specific treatments," said study leader Dr. Matthias Zilbauer. He is a lecturer in the department of pediatrics at the University of Cambridge in the United Kingdom.

"Our results indicate there might be a reprogramming of specific gut cell functions in Crohn's disease," he said in a university news release. "We don't know whether this is the cause of the disease or a consequence of it, but either way it is an exciting step in helping us to better understand the condition."

The researchers also found that lab-grown models known as "mini-guts" undergo cellular changes similar to those in a developing fetus. This suggests that such models could become an important tool for future research into very early gut development and associated diseases.

"From my own experience, we're diagnosing Crohn's disease in younger and younger children, some even under the age of 5 -- it's very much an emerging disease. It's a really nasty, lifelong condition, and when children are diagnosed, the whole family is affected," Zilbauer said. "We are determined to advance our knowledge in this area, and hopefully improve the lives of these children in the future."

More information

The Crohn's & Colitis Foundation has more on Crohn's disease.

SOURCE: University of Cambridge, news release, Dec. 7, 2020