24-Hour Crisis Hotline: (877)SAFEGBC or (877)723-3422 Mental Health & Substance Abuse Issues

6502 Nursery Drive, Suite 100
Victoria, TX 77904
(361)575-0611
Fax: (361)578-5500
Regular Hours: M-Fri 8am - 5pm
Every 3rd Thurs of the Month - Extended Hours Until 7 pm

Diabetes
Resources
Basic InformationLatest News
Statins: Good for the Heart, Maybe Not So Good for DiabetesMedtronic Expands Recall Of Thousands of Insulin PumpsScientists Untangle Why Diabetes Might Raise Alzheimer's RiskWhat Blood Sugar Levels Best Protect Against Heart Trouble in Those With Diabetes?Osteoporosis Drug May Keep Type 2 Diabetes at BayIs Insulin Resistance a Recipe for Depression?Doctors Often Miss Signs of Type 1 Diabetes in KidsBlack Americans, Mexican Americans Develop Diabetes Earlier in LifeAHA News: How a Simple Tape Measure May Help Predict Diabetes in Black AdultsExpert Panel Lowers Routine Screening Age for Diabetes to 35Dangerous Diabetes Tied to Pregnancy Is on the RiseDiabetes in Pregnancy Tied to Eye Issues in KidsDiabetes-Linked Amputations: Your Race, State MattersDiet Key to Better Health in People With DiabetesWhen Deductibles Rise, More Diabetes Patients Skip Their MedsType 2 Diabetes in Teens Can Bring Dangerous Complications in 20sFDA OKs Automatic Use of a Cheaper Generic  InsulinAHA News: Diabetes and Dementia Risk: Another Good Reason to Keep Blood Sugar in CheckAmericans With Diabetes Were Hit Hard by COVID PandemicAHA News: The Challenge of Diabetes in the Black Community Needs Comprehensive SolutionsWhich Blood Sugar Meds Work Best Against Type 2 Diabetes?Walmart to Offer Low-Priced InsulinPoorly Managed Diabetes Raises Odds for More Severe COVIDWeekly Injected Drug Could Boost Outcomes for Patients With Type 2 DiabetesLockdown Weight Gain May Have Caused Surge in New Diabetes Cases in KidsAmerica Is Losing the War Against DiabetesA Fruitful Approach to Preventing DiabetesIn People With Type 1 Diabetes, Poor Blood Sugar Control Could Raise Dementia RiskBlood Sugar Tests Using Sweat, Not Blood? They Could Be on the WayWhen Diabetes Strikes in Pregnancy, Do Women Eat Healthier?Being a 'Night Owl' Raises Odds for Diabetes If You're Obese'Prediabetes' Raises Odds for Heart Attack, StrokeDementia Risk Rises as Years Lived With Type 2 Diabetes IncreasesCOVID-19 and Advanced Diabetes Can Be a Deadly Mix: StudyPandemic May Be Upping Cases of Severe Complication in Kids With DiabetesDiabetes Can Lead to Amputations, But Stem Cell Treatment Offers HopeCan a Drug Help Prevent Diabetic Vision Loss?Diabetes Is Deadlier for Black Americans: StudyLockdowns Gave Boost to Type 1 Diabetes Control in KidsComing Soon: Once-a-Week Insulin Injections?Common Type 2 Diabetes Meds Won't Raise Breast Cancer Risk: StudySome Kids With Type 1 Diabetes Face High Risk of Severe COVID-19Breakfast Timing Could Affect Your Odds for DiabetesBegin Routine Diabetes Screening at 35 for Overweight, Obese Americans: Task ForceCould a Drug Prevent Type 1 Diabetes in Those at Risk?Women With Type 1 Diabetes May Have Fewer Childbearing Years: StudyMeeting the Challenges of Type 1 Diabetes in the Teen YearsA Fifth of COVID Patients With Diabetes Die Within 1 Month of Hospitalization'Prediabetes' May Be Harming Your Brain, Study FindsDoes 'Prediabetes' Lead to Full-Blown Diabetes? Age May Be Key
Links
Related Topics

Medical Disorders

Diabetes Can Lead to Amputations, But Stem Cell Treatment Offers Hope

HealthDay News
by By Amy Norton HealthDay Reporter
Updated: Apr 14th 2021

new article illustration

WEDNESDAY, April 14, 2021 (HealthDay News) -- One of the most dangerous complications of diabetes is a foot ulcer that won't heal, but now a preliminary study finds that a type of stem cell found in body fat may be a powerful remedy for these severe foot wounds.

The study included 63 patients with non-healing diabetic foot ulcers who were given injections of cells from their own body fat. Over the next year, the treatment healed the ulcers in most patients.

Researchers said the study — conducted in Nicaragua — lays the groundwork for a similar trial in the United States, to replicate the findings.

Diabetic foot ulcers are open sores or wounds that affect roughly 15% of people with diabetes, according to the American Podiatric Medical Association (APMA). For some, the wounds refuse to heal and can become infected -- sometimes leading to amputation.

In the United States alone, studies show that more than half of all amputations are diabetes-related -- and non-healing foot ulcers are usually the reason why.

People with diabetes are vulnerable to foot ulcers for several reasons, explained study author Dr. Michael Carstens.

Over time, chronically high blood sugar can damage nerves in the feet, leading to a loss of sensation. That means sores or cuts can go unnoticed until they worsen and become infected. Making matters worse, diabetes damages the body's small blood vessels, which impairs blood flow to the feet -- interfering with the natural wound-healing process.

On top of that, many people with diabetes also have blockages in larger arteries, including those in the legs, said Carstens, of Wake Forest University's Institute for Regenerative Medicine, in Winston-Salem, N.C.

Diabetic foot ulcers can often be treated with measures like applying medication or dressings to the wound, as well as surgical debridement -- where a doctor removes dead skin and tissue to create a "new" wound that may heal better.

Still, the APMA says, around 6% of people with diabetic ulcers end up in the hospital due to an infection or other complication.

For their study, Carstens' team turned to stem cells to try to heal severe wounds in diabetes patients who were candidates for amputation.

"They had critical-size wounds," Carstens noted. "There was no way they were going to heal on their own."

Specifically, researchers harvested a collection of cells called stromal vascular fraction from patients' body fat. Among that collection is a type of "adult" stem cell called mesenchymal stem cells (MSCs).

MSCs give rise to certain more mature cell types, including cartilage and muscle.

Researchers injected the cells into and around patients' wounds, and along arteries in the lower leg. Six months later, 51 of the 63 patients were showing complete closure of the ulcer, while another eight had at least a 75% closure.

Of the remaining four, three needed amputations and one died -- from heart complications unrelated to the treatment, the researchers said.

One year out, 50 patients had completely healed wounds, while another four had at least 85% healing. The remaining five patients had died -- also from heart-related causes.

According to Carstens, MSCs appear to work by producing chemicals that spur new blood vessel growth, allowing for wound repair.

The findings were recently published in the journal Stem Cells Translational Medicine.

The general tactic of using stem cells for diabetic foot ulcers is not new; doctors can already use cells derived from the amniotic membrane of the placenta.

Dr. Jeffrey Ross, an APMA spokesman, said he's personally found amniotic membrane cells to be very effective in wound healing.

The cells are retrieved from the placenta of babies born by cesarean section, explained Ross, who is also an associate professor of surgery at Baylor College of Medicine in Houston.

Various companies market products containing frozen or dehydrated amniotic membrane cells that can be applied to diabetic foot ulcers.

Ross did say the wound healing in the new study was "impressive." In three patients who'd had wounds so severe their tendons were exposed, the newly developed tissue was capable of covering the tendons -- which he pointed out is difficult to achieve.

Ross added, though, that he would have liked to see more intensive follow-up of the patients. The intervals between evaluations were "too far apart," he said.

It's not clear whether cells derived from patients' fat could be any better than the amniotic cells already on the market, according to Ross. It would take head-to-head studies to determine that, he said.

But in general, Ross said, cell-based therapies -- harnessing the body's own healing powers -- are the wave of the future.

More information

The American Podiatric Medical Association has more on diabetic foot ulcers.


SOURCES: Michael Carstens, MD, PhD, assistant instructor, Institute for Regenerative Medicine, Wake Forest University, Winston-Salem, N.C.; Jeffrey Ross, MD, DPM, associate professor, surgery, Baylor College of Medicine, Houston; Stem Cells Translational Medicine online, April 7, 2021