24-Hour Crisis Hotline: (877)SAFEGBC or (877)723-3422 Mental Health & Substance Abuse Issues

6502 Nursery Drive, Suite 100
Victoria, TX 77904
Fax: (361)578-5500
Regular Hours: M-Fri 8am - 5pm
Every 3rd Thurs of the Month - Extended Hours Until 7 pm

Basic InformationLatest News
Statins: Good for the Heart, Maybe Not So Good for DiabetesMedtronic Expands Recall Of Thousands of Insulin PumpsScientists Untangle Why Diabetes Might Raise Alzheimer's RiskWhat Blood Sugar Levels Best Protect Against Heart Trouble in Those With Diabetes?Osteoporosis Drug May Keep Type 2 Diabetes at BayIs Insulin Resistance a Recipe for Depression?Doctors Often Miss Signs of Type 1 Diabetes in KidsBlack Americans, Mexican Americans Develop Diabetes Earlier in LifeAHA News: How a Simple Tape Measure May Help Predict Diabetes in Black AdultsExpert Panel Lowers Routine Screening Age for Diabetes to 35Dangerous Diabetes Tied to Pregnancy Is on the RiseDiabetes in Pregnancy Tied to Eye Issues in KidsDiabetes-Linked Amputations: Your Race, State MattersDiet Key to Better Health in People With DiabetesWhen Deductibles Rise, More Diabetes Patients Skip Their MedsType 2 Diabetes in Teens Can Bring Dangerous Complications in 20sFDA OKs Automatic Use of a Cheaper GenericĀ  InsulinAHA News: Diabetes and Dementia Risk: Another Good Reason to Keep Blood Sugar in CheckAmericans With Diabetes Were Hit Hard by COVID PandemicAHA News: The Challenge of Diabetes in the Black Community Needs Comprehensive SolutionsWhich Blood Sugar Meds Work Best Against Type 2 Diabetes?Walmart to Offer Low-Priced InsulinPoorly Managed Diabetes Raises Odds for More Severe COVIDWeekly Injected Drug Could Boost Outcomes for Patients With Type 2 DiabetesLockdown Weight Gain May Have Caused Surge in New Diabetes Cases in KidsAmerica Is Losing the War Against DiabetesA Fruitful Approach to Preventing DiabetesIn People With Type 1 Diabetes, Poor Blood Sugar Control Could Raise Dementia RiskBlood Sugar Tests Using Sweat, Not Blood? They Could Be on the WayWhen Diabetes Strikes in Pregnancy, Do Women Eat Healthier?Being a 'Night Owl' Raises Odds for Diabetes If You're Obese'Prediabetes' Raises Odds for Heart Attack, StrokeDementia Risk Rises as Years Lived With Type 2 Diabetes IncreasesCOVID-19 and Advanced Diabetes Can Be a Deadly Mix: StudyPandemic May Be Upping Cases of Severe Complication in Kids With DiabetesDiabetes Can Lead to Amputations, But Stem Cell Treatment Offers HopeCan a Drug Help Prevent Diabetic Vision Loss?Diabetes Is Deadlier for Black Americans: StudyLockdowns Gave Boost to Type 1 Diabetes Control in KidsComing Soon: Once-a-Week Insulin Injections?Common Type 2 Diabetes Meds Won't Raise Breast Cancer Risk: StudySome Kids With Type 1 Diabetes Face High Risk of Severe COVID-19Breakfast Timing Could Affect Your Odds for DiabetesBegin Routine Diabetes Screening at 35 for Overweight, Obese Americans: Task ForceCould a Drug Prevent Type 1 Diabetes in Those at Risk?Women With Type 1 Diabetes May Have Fewer Childbearing Years: StudyMeeting the Challenges of Type 1 Diabetes in the Teen YearsA Fifth of COVID Patients With Diabetes Die Within 1 Month of Hospitalization'Prediabetes' May Be Harming Your Brain, Study FindsDoes 'Prediabetes' Lead to Full-Blown Diabetes? Age May Be Key
Related Topics

Medical Disorders

Weekly Injected Drug Could Boost Outcomes for Patients With Type 2 Diabetes

HealthDay News
by By Robert Preidt and Ernie Mundell HealthDay Reporters
Updated: Jun 29th 2021

new article illustration

TUESDAY, June 29, 2021 (HealthDay News) -- People with type 2 diabetes face heightened risks for heart attack and stroke, as well as progressive kidney disease. But a new once-a-week injected drug called efpeglenatide could greatly reduce their odds for those outcomes, new research shows.

The clinical trial was conducted in over 28 nations and involved more than 4,000 patients with type 2 diabetes.

Over two years, patients who received weekly injections of efpeglenatide had a 27% lower risk of a heart attack, stroke, cardiovascular-related death or death from any cause, as well as a 32% lower risk of kidney disease progression, compared to those who received a placebo.

The study, funded by the drug's maker, Sanofi, was presented Monday at the (virtual) annual meeting of the American Diabetes Association (ADA), and was published simultaneously in the New England Journal of Medicine.

The trial confirms efpeglenatide "as an effective cardioprotective drug for type 2 diabetes patients with cardiovascular and/or kidney disease," said study lead author Dr. Hertzel Gerstein, professor at McMaster University and Hamilton Health Sciences, in Hamilton, Canada.

"We are encouraged that this once-a-week injection safely and effectively reduced cardiovascular and progression of kidney disease in patients with long-standing diabetes who had a high prevalence of cardiovascular and kidney disease," he said in an ADA news release.

As the researchers explained, efpeglenatide is in a class of medicines known as glucagon-like peptide-1 receptor agonists (GLP-1 RA), which are used to treat diabetes and reduce blood sugar levels, weight and high blood pressure.

Previous research has shown that GLP-1 RA drugs that focus on GLP-1 can reduce heart and kidney problems.

That's no small thing for the more than 32 million Americans diagnosed with diabetes. According to the researchers, most (98%) of adults with type 2 diabetes have at least one other chronic condition, including conditions that affect the heart and kidneys.

About 1 in 4 (24%) of type 2 diabetes patients have kidney disease, 22% have cardiovascular disease, and 82% have hypertension -- a leading cause of heart disease.

In the new clinical trial, Gerstein's group tracked outcomes for people with type 2 diabetes. Patients took either efpeglenatide alone or in conjunction with a drug from another commonly used class of medicines called SGLT2 inhibitors.

The benefits seen from efpeglenatide were similar with or without the use of an SGLT2 inhibitor drug, the team noted. Use of the drug brought no serious side effects.

Two experts in diabetes care who weren't involved in the study said the findings were encouraging.

Dr. Minisha Sood, an endocrinologist at Lenox Hill Hospital in New York City, said the average patient in the trial -- burdened by the threat of heart and kidney problems -- represents "the classic person with type 2 diabetes in the United States."

She said the trial did have one flaw, however: It only compared efpeglenatide to placebo, not to high-dose semaglutide (Ozempic), another effective drug often used in this type of patient.

Dr. Barbara Keber directs family medicine at Glen Cove Hospital in Glen Cove, N.Y. She said the new trial showed that efpeglenatide is both effective and safe.

That's important, Keber noted, because "prior medications which have shown improvement in cardiovascular disease have shown some increases in side effects."

Then there's an issue around convenience.

"The weekly injection gives the advantage of fewer injections, which makes it easier for the patient," Keber said. Weekly scheduling also reduces the odds for hypoglycemia (low blood sugar) and "allows for tighter control with the GLP1 RA [drug. It is] therefore safer for patients who may otherwise develop hypoglycemia with insulin or other agents when tight control is attempted," she said.

More information

The American Academy of Family Physicians has more on diabetes.

SOURCES: Minisha Sood, MD, endocrinologist, Lenox Hill Hospital, New York City; Barbara Keber, MD, chair, family medicine, Glen Cove Hospital, Glen Cove, N.Y.; American Diabetes Association, news release, June 28, 2021