24-Hour Crisis Hotline: (877)SAFEGBC or (877)723-3422 Mental Health & Substance Abuse Issues

6502 Nursery Drive, Suite 100
Victoria, TX 77904
(361)575-0611
Fax: (361)578-5500
Regular Hours: M-Fri 8am - 5pm
Every 3rd Thurs of the Month - Extended Hours Until 7 pm

Alzheimers Disease and other Cognitive Disorders
Resources
Basic Information
Introduction & Causes of Cognitive DisordersDementiaAlzheimer's DiseaseOther Cognitive DisordersDementia Coping Skills & Behavior ManagementTraumatic Brain Injury (TBI)Conclusion and Resources
More InformationLatest News
Multigenerational Study Finds Links Between ADHD, Dementia RiskMost Alzheimer's Patients Wouldn't Have Qualified for Controversial Drug's Trial: StudyCould Traffic Noise Raise Your Odds for Dementia?AHA News: What Are Researchers Doing to Stop Dementia?A Mentally Challenging Job Could Help Ward Off DementiaDirty Air, Higher Dementia Risk?An ALS Drug Shows Early Promise Against Alzheimer'sAHA News: Dementia Can Complicate Heart Recovery and TreatmentDeaths From Alzheimer's Far More Common in Rural AmericaCould COVID-19 Accelerate Alzheimer's Symptoms?Dementia Cases Will Nearly Triple Worldwide by 2050: StudyFDA Panel Advisor Who Panned New Alzheimer's Drug Speaks Out'Light Flash' Treatment Might Help Slow Alzheimer'sCleaning Up the Air Could Help Prevent Alzheimer'sLong-Term Outlook for Most With Serious Brain Injury Is Better Than ThoughtDrug Shows Promise in Easing Dementia-Linked PsychosisAHA News: Diabetes and Dementia Risk: Another Good Reason to Keep Blood Sugar in Check1 in 20 Cases of Dementia Occurs in People Under 65Could Menopausal Hormone Therapy Reduce Women's Odds for Dementia?Reading, Puzzles May Delay Alzheimer's by 5 Years: StudyTwo Major Health Systems Won't Administer Controversial New Alzheimer's DrugMost Marriages Survive a Spouse's Brain InjuryMedicare Mulls Coverage for Controversial Alzheimer's DrugFDA Head Asks for Investigation Into Alzheimer's Drug ApprovalNew Prescribing Instructions Tighten Use of Controversial Alzheimer's DrugMissing Teeth, Higher Odds for Dementia?AHA News: Smoking Harms the Brain, Raises Dementia Risk – But Not If You QuitHealthy Living Can Lower Your Odds for Alzheimer'sKeeping Same Nurse for All Home Health Care May Be Crucial for Dementia PatientsMost Cases of Dementia in U.S. Seniors Go Undiagnosed: StudyLilly to Seek FDA Approval for New Alzheimer's DrugCould a Type of Statin Raise Dementia Risks?Good News, Bad News From Alzheimer's Vaccine TrialPoor Sleep After Head Injury Could Point to Dementia RiskFDA Approves Alzheimer's Drug Despite Expert Panel's ObjectionsFDA Defends Approval of Controversial Alzheimer's DrugPeople of Color Have Twice the Risk of Dying After Brain Injury, Study FindsIn People With Type 1 Diabetes, Poor Blood Sugar Control Could Raise Dementia RiskThere's Been a Shift in Who's Funding Alzheimer's ResearchHealthy Living Helps Prevent Dementia, Even If It Runs in the FamilyAHA News: Is It Normal Aging or Early Signs of Dementia?Failing Kidneys Could Bring Higher Dementia RiskDementia Risk Rises as Years Lived With Type 2 Diabetes IncreasesHead Injury, Alzheimer's Appear to Affect Brain in Similar WaysBrain Injuries Raise Long-Term Risk of StrokeResearch Shows Links Between Gum Disease and Alzheimer'sAssisted Living Centers Can Do More for Dementia Patients, Experts SayDiminished Hearing, Vision Together Could Be Risk Factor for Dementia6 Steps to Reduce Caregiver StressLoneliness in Mid-Life Linked to Higher Odds for Alzheimer's
Questions and AnswersLinks
Related Topics

An ALS Drug Shows Early Promise Against Alzheimer's

HealthDay News
by Robert Preidt
Updated: Aug 2nd 2021

new article illustration

MONDAY, Aug. 2, 2021 (HealthDay News) -- Could a drug used to treat amyotrophic lateral sclerosis (ALS) help people with mild Alzheimer's disease?

The results of a small new study suggest the strategy could work.

Riluzole has been used for more than 20 years to slow the progression of ALS, commonly called Lou Gehrig's disease. This phase 2 study found that the drug slowed brain metabolic decline and had a positive effect on cognition in people with mild Alzheimer's.

It included 50 patients ages 50 to 90 who received either the drug (26) or a placebo (24) twice daily for six months.

"Using two types of brain scans as biomarkers -- this study was able to measure improvements in brain metabolism among treated patients and correlate those improvements with cognitive changes and disease progression," said study co-author Dr. Howard Fillit, founding executive director and chief science officer of the Alzheimer's Drug Discovery Foundation.

"It is a repurposed drug, which helps speed the research process. It targets an important and understudied biological mechanism that goes awry with aging, and the rigorous design of this trial measured both biomarker and clinical outcomes," Fillit noted in a foundation news release.

Riluzole targets a neurotransmitter in the brain called glutamate, which plays a crucial role in the ability of nerve cells to send signals to one another. Glutamate dysregulation is believed to start a cycle of toxicity involved in Alzheimer's disease, the researchers said.

The study found significant changes in glutamate levels in patients who received the drug. Rates of adverse events were the same among patients who took riluzole and those who took the placebo.

The results were recently published online in the journal Brain.

These findings support a phase 3 trial with larger numbers of patients followed for a longer period of time to further assess the safety and efficacy of the drug in Alzheimer's patients, said lead investigator Dr. Ana Pereira, assistant professor of neurology and neuroscience at the Icahn School of Medicine at Mount Sinai in New York City.

More information

The Alzheimer's Association has more on Alzheimer's disease.

SOURCE: Alzheimer's Drug Discovery Foundation, news release, July 28, 2021